G-quadruplexes, a family of tetraplex helical nucleic acid topologies, have emerged in
recent years as novel targets, with untapped potential for anticancer research. Their …

Conspectus Biomimetics is defined as a “practice of making technological design that copies
natural processes”, with the idea that “nature has already solved the challenges we are …

G-quadruplexes have gained prominence over the past two decades for their role in gene
regulation, control of anti-tumour activity and ageing. The physiological relevance and …

Abstract Development of probes that can discriminate G-quadruplex (GQ) structures and
indentify efficient GQ binders on the basis of topology and nucleic acid type is highly desired …

G-quadruplexes (G4s) continue to gather wide attention in the field of chemical biology as
their prevalence in the human genome and transcriptome strongly suggests that they play …

We previously identified quinoline‐based oligoamide helical foldamers and a trimeric
macrocycle as selective ligands of DNA quadruplexes. Their helical structures might permit …

Quinoline‐based oligoamide foldamers have been identified as a potent class of ligands for
G‐quadruplex DNA. Their helical structure is thought to target G‐quadruplex loops or …

A twice-as-smart ligand is a small molecule that experiences a structural switch upon
interaction with its target (ie, smart ligand) that concomitantly triggers its fluorescence (ie …

Scientists are currently truly committed to enhance the specificity of chemotherapeutics that
target DNA. To this end, sequence-specific drugs have progressively given way to structure …

The search for convenient molecular probes for detecting DNA and RNA quadruplexes in
vitro is marked by a rapid pace of progress, spurred on by the multiple roles these higher …