[HTML][HTML] Recent developments in small-molecule ligands of medicinal relevance for harnessing the anticancer potential of G-quadruplexes
L Savva, SN Georgiades - Molecules, 2021 - mdpi.com
G-quadruplexes, a family of tetraplex helical nucleic acid topologies, have emerged in
recent years as novel targets, with untapped potential for anticancer research. Their …
recent years as novel targets, with untapped potential for anticancer research. Their …
Template-assembled synthetic G-quartets (TASQs): multiTASQing molecular tools for investigating DNA and RNA G-quadruplex biology
D Monchaud - Accounts of Chemical Research, 2023 - ACS Publications
Conspectus Biomimetics is defined as a “practice of making technological design that copies
natural processes”, with the idea that “nature has already solved the challenges we are …
natural processes”, with the idea that “nature has already solved the challenges we are …
[HTML][HTML] Small molecule fluorescent probes for G-quadruplex visualization as potential cancer theranostic agents
G-quadruplexes have gained prominence over the past two decades for their role in gene
regulation, control of anti-tumour activity and ageing. The physiological relevance and …
regulation, control of anti-tumour activity and ageing. The physiological relevance and …
Conformation-sensitive nucleoside analogues as topology-specific fluorescence turn-on probes for DNA and RNA G-quadruplexes
AA Tanpure, SG Srivatsan - Nucleic acids research, 2015 - academic.oup.com
Abstract Development of probes that can discriminate G-quadruplex (GQ) structures and
indentify efficient GQ binders on the basis of topology and nucleic acid type is highly desired …
indentify efficient GQ binders on the basis of topology and nucleic acid type is highly desired …
Biomimetic, smart, and multivalent ligands for G-quadruplex isolation and bioorthogonal imaging
FR Sperti, T Charbonnier, P Lejault, J Zell… - ACS Chemical …, 2021 - ACS Publications
G-quadruplexes (G4s) continue to gather wide attention in the field of chemical biology as
their prevalence in the human genome and transcriptome strongly suggests that they play …
their prevalence in the human genome and transcriptome strongly suggests that they play …
Targeting DNA G‐Quadruplexes with Helical Small Molecules
We previously identified quinoline‐based oligoamide helical foldamers and a trimeric
macrocycle as selective ligands of DNA quadruplexes. Their helical structures might permit …
macrocycle as selective ligands of DNA quadruplexes. Their helical structures might permit …
Multivalent Interactions between an Aromatic Helical Foldamer and a DNA G‐Quadruplex in the Solid State
PK Mandal, B Baptiste, B Langlois d'Estaintot… - …, 2016 - Wiley Online Library
Quinoline‐based oligoamide foldamers have been identified as a potent class of ligands for
G‐quadruplex DNA. Their helical structure is thought to target G‐quadruplex loops or …
G‐quadruplex DNA. Their helical structure is thought to target G‐quadruplex loops or …
[HTML][HTML] Computational understanding and experimental characterization of twice-as-smart quadruplex ligands as chemical sensors of bacterial nucleotide second …
A twice-as-smart ligand is a small molecule that experiences a structural switch upon
interaction with its target (ie, smart ligand) that concomitantly triggers its fluorescence (ie …
interaction with its target (ie, smart ligand) that concomitantly triggers its fluorescence (ie …
Surface-promoted aggregation of amphiphilic quadruplex ligands drives their selectivity for alternative DNA structures
A Laguerre, Y Chang, M Pirrotta, N Desbois… - Organic & …, 2015 - pubs.rsc.org
Scientists are currently truly committed to enhance the specificity of chemotherapeutics that
target DNA. To this end, sequence-specific drugs have progressively given way to structure …
target DNA. To this end, sequence-specific drugs have progressively given way to structure …
DNA structure-specific sensitization of a metalloporphyrin leads to an efficient in vitro quadruplex detection molecular tool
PD Diabate, A Laguerre, M Pirrotta, N Desbois… - New Journal of …, 2016 - pubs.rsc.org
The search for convenient molecular probes for detecting DNA and RNA quadruplexes in
vitro is marked by a rapid pace of progress, spurred on by the multiple roles these higher …
vitro is marked by a rapid pace of progress, spurred on by the multiple roles these higher …