Nitric oxide (NO) is a small free radical with critical signaling roles in physiology and
pathophysiology. The generation of sufficient NO levels to regulate the resistance of the …

During the development of the pulmonary vasculature in the fetus, many structural and
functional changes occur to prepare the lung for the transition to air breathing. The …

Hypertension is a major contributor to the development of renal failure, cardiovascular
disease, and stroke. These pathologies are associated with vascular functional and …

Endothelial nitric oxide synthase (eNOS) serves as a critical enzyme in maintaining vascular
pressure by producing nitric oxide (NO); hence, it has a crucial role in the regulation of …

Atherosclerosis is a progressive and multifactorial disease which occurs under the influence
of various risk factors including endothelial dysfunction (ED), oxidative stress, and low …

Nitric oxide (NO) produced by endothelial NO synthase (eNOS) represents an anti-
atherosclerotic principle. NO bioavailability is decreased in atherosclerosis due to increased …

The endothelium is an active tissue that plays a pivotal role in maintaining cardiovascular
homeostasis. The endothelium ensures the quality of both the global and microcirculation. It …

Elevated production of prostanoids from the constitutive (COX-1) or inducible (COX-2) cyclo-
oxygenases has been involved in the alterations in vascular function, structure and …

Most mammalian tissue cells experience oxygen partial pressures in vivo equivalent to 1–
6% O2 (ie, physioxia). In standard cell culture, however, headspace O2 levels are usually …

Nonenzymatic nitric oxide (NO) generation via the reduction of nitrate and nitrite ions, along
with remarkably high levels of nitrate ions in skeletal muscle, have been described recently …