Neurodegenerative and neuropsychiatric diseases are increasingly affecting individuals'
quality of life, thus increasing their cost to social and health systems. These diseases have …

Traditionally, drugs are monovalent, targeting only one site on the protein surface. This
includes orthosteric and allosteric drugs, which bind the protein at orthosteric and allosteric …

Antibiotic resistance has become an increasing challenge in the treatment of various
infectious diseases, especially those associated with biofilm formation on biotic and abiotic …

Natural and non-natural hexahydrocannabinols (HHC) were first described in 1940 by Adam
and in late 2021 arose on the drug market in the United States and in some European …

Despite the very large number of phytocannabinoids isolated from Cannabis (Cannabis
sativa L.), bioactivity studies have long remained focused on the so called “Big Four”[Δ9 …

Cannabis sativa is one of the first medicinal plants used by humans. Its medical use remains
controversial because it is a psychotropic drug whose use has been banned. Recently …

Increased usage of recreational and medically indicated cannabinoid compounds has been
an undeniable reality for anesthesiologists in recent years. These compounds' complicated …

Cannabis (Cannabis sativa L.) is a dioecious plant cultivated worldwide for thousands of
years. Besides the narcotic and therapeutic effects, Cannabis can be used as raw materials …

(−)-Δ9-trans-tetrahydrocannabinol (THC), which is the principal psychoactive constituent of
Cannabis, mediates its action by binding to two members of the G-protein-coupled receptor …

Early flow cytometry studies revealed T cell activation in major depressive disorder (MDD).
MDD is characterised by activation of the immune-inflammatory response system (IRS) and …