Rho guanosine triphosphatases (GTPases) are key regulators in a number of cellular
functions, including actin cytoskeleton remodeling and vesicle traffic. Traditionally, Rho …

The bioactive sphingolipid metabolite, sphingosine 1-phosphate (S1P), and the signaling
pathways triggered by its binding to specific G protein-coupled receptors play a critical …

Aging affects the body composition and balance of energy metabolism. Here, we collected in
a single work several physiological parameters to show how aging and sex differences can …

Obesity is a disease characterized by the exacerbated increase of adipose tissue. A
possible way to decrease the harmful effects of excessive adipose tissue is to increase the …

Epicardial adipose tissue (EAT) is a metabolically active organ which generates
inflammatory cytokines. Thickness of EAT is associated with onset and development of heart …

Aims Obesity, aging, and physical training are factors influencing pancreatic functional and
morphological parameters. Aiming to clarify the impact of the interaction of these factors, we …

Physical exercise is considered a fundamental strategy in improving insulin sensitivity and
glucose uptake in skeletal muscle. However, the molecular mechanisms underlying this …

Purpose Aging is associated with changes in glucose homeostasis related to both
decreased insulin secretion and/or impaired insulin action, contributing to the high …

White adipose tissue (WAT) controls energy storage, expenditure, and endocrine function.
Rho-kinase (ROCK) is related to impaired thermogenesis, downregulation of preadipocyte …

The RhoA/ROCK-mediated actin cytoskeleton dynamics have been implicated in
adipogenesis. The two ROCK isoforms, ROCK1 and ROCK2, are highly homologous. The …