Turmeric (Curcuma longa), a rhizomatous herbaceous perennial plant of the ginger family,
has been used for the treatment of diabetes in Ayurvedic and traditional Chinese medicine …

Highlights•Epigenetics has emerged as an area of interest for novel drug
discovery.•Epigenetic drugs can revolutionize the treatment of diabetes and …

Genome-wide association studies (GWAS) have consistently implicated noncoding variation
within the TCF7L2 locus with type 2 diabetes (T2D) risk. While this locus represents the …

The proinflammatory cytokine, IL-1β (Interleukin-1β) is a significant determinant of
pancreatic apoptosis and cell death that are common characteristics during diabetes. Using …

Transcription factor-7-like-2 (TCF7L2), a vital member of the T-cell factor/lymphoid enhancer
factor (TCF/LEF) family, plays an important role in normal human physiological and …

ABSTRACT OBJECTIVES: We aimed to investigate the effects of juglone on angiogenesis,
metastasis and cell proliferation processes in pancreatic cancer (PC) and to understand …

Abstract TCF7L2 and SLC30A8 have been found to be associated with type 2 diabetes
mellitus (T2DM) as well as with impaired proinsulin processing recently, enzymes encoded …

Background Hyperglycemia induces activation of the c-Jun N-terminal kinase (JNK)
pathway, which suppresses insulin gene expression and reduces DNA binding of pancreatic …

Multiple trauma has serious complications, which increases the risk of morbidity and
mortality in the patients. This study aimed to evaluate the impact of supplementation with …

Abstract Endocrinology and Metabolism Research Institute (EMRI) was founded in 1993.
EMRI progressed step by step from inception and reached to its maturation during the past …