Nucleoside triphosphates—building blocks for the modification of nucleic acids

M Hollenstein - Molecules, 2012 - mdpi.com
Nucleoside triphosphates are moldable entities that can easily be functionalized at various
locations. The enzymatic polymerization of these modified triphosphate analogues …

Chemical methods for the modification of RNA

M Flamme, LK McKenzie, I Sarac, M Hollenstein - Methods, 2019 - Elsevier
RNA is often considered as being the vector for the transmission of genetic information from
DNA to the protein synthesis machinery. However, besides translation RNA participates in a …

Generation of aptamers with an expanded chemical repertoire

S Diafa, M Hollenstein - Molecules, 2015 - mdpi.com
The enzymatic co-polymerization of modified nucleoside triphosphates (dN* TPs and N*
TPs) is a versatile method for the expansion and exploration of expanded chemical space in …

Recent advances in computational 31P NMR: Part 1. Chemical shifts

LB Krivdin - Magnetic Resonance in Chemistry, 2020 - Wiley Online Library
This is the first part of two closely related reviews dealing with the computation of
phosphorus‐31 nuclear magnetic resonance chemical shifts in a wide series of …

Recent advances in the syntheses of nucleoside triphosphates

AR Kore, B Srinivasan - Current Organic Synthesis, 2013 - ingentaconnect.com
The present review compiles significant advances in different synthetic strategies to obtain
various nucleoside triphosphates, which are indispensable materials for variety of important …

Biochemistry of nucleic acids functionalized with sulfur, selenium, and tellurium: roles of the single-atom substitution

M Kaur, A Rob, J Caton-Williams… - … chemistry: The biological …, 2013 - ACS Publications
Nucleic acids and their modifications are instrumental in discovering functional
oligonucleotides as important biochemical and therapeutic agents. In the search of bioactive …

Incorporation of 4′-C-aminomethyl-2′-O-methylthymidine into DNA by thermophilic DNA polymerases

GN Nawale, KR Gore, C Höbartner… - Chemical …, 2012 - pubs.rsc.org
The dual modified nucleotide 4′-C-aminomethyl-2′-O-methylthymidine 5′-triphosphate
was synthesized and enzymatically incorporated into DNA by the thermophilic DNA …

Synthesis of selenomethylene-locked nucleic acid (SeLNA)-modified oligonucleotides by polymerases

M Wheeler, A Chardon, A Goubet, K Morihiro… - Chemical …, 2012 - pubs.rsc.org
Enzymatic recognition of SeLNA nucleotides was investigated. KOD XL DNA polymerase
was found to be an efficient enzyme in primer extension reactions. Polymerase chain …

Unexpected Loss of Stereoselectivity in Ring‐Opening Reaction of 2‐Alkoxy‐2‐Thio‐1, 3, 2‐Oxathiaphospholanes With a Pyrophosphate Anion

P Guga, A Tomaszewska - Chirality, 2015 - Wiley Online Library
A reaction of DBU promoted ring opening in nucleoside‐3'‐O‐and nucleoside‐5'‐O‐(2‐thio‐
4, 4‐pentamethylene‐1, 3, 2‐oxathiaphospholane) monomers with a pyrophosphate or a …

[PDF][PDF] A theoretical and experimental NMR study of the prototropic tautomerism of tris (tetrabutylammonium) hydrogen pyrophosphate salt in solution and in the solid …

D Sanz, RM Claramunt, I Alkorta, J Elguero - Afinidad, 2015 - raco.cat
The structure of tris (tetrabutylammonium) hydrogen pyrophosphate (HPP) has been studied
in solution and in the solid-state by 31P NMR. GIAO/DFT calculations of the isolated …