Natural products have historically been of crucial importance in the identification and
development of antibacterial agents. Interest in these systems has waned in recent years …

Antibacterial drugs face increasing challenges due to drug resistance and adverse
reactions, which has created a pressing need for the discovery and development of novel …

Cancer is one of the diseases with high morbidity and mortality on a global scale.
Chemotherapy remains the primary treatment option for most cancer patients, including …

Natural products have historically been, and continue to be, an invaluable source for the
discovery of various therapeutic agents. Oridonin, a natural diterpenoid widely applied in …

Natural products (NPs) have played a key role in drug discovery and are still a prolific
source of novel lead compounds or pharmacophores for medicinal chemistry …

Overexpression or activation of AKT is very well known to control cell growth, survival, and
gene expression in solid tumors. Oridonin, an inflammatory medical and diterpenoid …

Pyrazine is a six-membered heterocyclic ring containing nitrogen, and many of its
derivatives are biologically active compounds. References have been downloaded through …

Oridonin belongs to ent-kaurane tetracyclic diterpenoid and was first isolated from Isodon
species. It exhibits inhibitory activities against a variety of tumor cells, and pharmacological …

Oridonin has attracted considerable attention in the last decade because of its anti-cancer
pharmacological properties. This ent-kaurane diterpenoid, isolated from the Chinese herb …

Triple-negative breast cancer (TNBC) is one of the most highly invasive and metastatic
breast cancers without safe and effective therapeutic drugs. The natural product oridonin is …