Autoimmune diseases (ADs) represent a heterogenous group of complex diseases with
increasing incidence in Western countries and are a major cause of morbidity …

Systemic sclerosis (SSc) is a rare multisystem autoimmune disease, characterized by
fibrosis, vasculopathy, and autoimmunity. Recent advances have highlighted the significant …

Systemic sclerosis (SSc) is a destructive connective tissue disease characterized by
dysregulation of the immune system and fibrosis in the skin and internal organs. The …

Systemic sclerosis (SSc) is an autoimmune disease with a poor prognosis. To date, the
pathogenesis of SSc is still unclear; moreover, its pathological conditions include …

Systemic sclerosis (SSc) is a complex, immune-mediated rheumatic disease characterised
by excessive extracellular matrix deposition in the skin and internal organs. B cell infiltration …

Systemic sclerosis (SSc) is an autoimmune, multi-organ, connective tissue disease
associated with significant morbidity and mortality. Conventional immunosuppressive …

A hallmark of disease pathogenesis of systemic sclerosis (SSc) is the presence of
autoreactive B cell responses targeting nuclear proteins. Almost all SSc-patients harbour …

Systemic sclerosis (SSc) is a chronic, autoimmune, multisystem disease characterized by
tissue fibrosis that, apart from the skin, may affect the lungs among other organs. B cells …

The pathogenesis of SSc is incompletely understood, but several lines of evidence suggest
that B cells are involved. Effector B (Beff) cells are hyperactivated and produce …

Systemic sclerosis (SSc) is a rare rheumatic disease characterised by inflammation,
vasculopathy and fibrosis of skin and internal organs. A common complication and a leading …