Pancreatic cancer (PC) is one of the most common malignancies. Surgical resection is a
potential curative approach for PC, but most patients are unsuitable for operations when at …

The dependency of the growth of tumors on blood vessels, once considered a doubtful
proposition, has become a major avenue of research and drug development. This review …

Tumor angiogenesis is recognized as a major therapeutic target in the fight against cancer.
The key involvement of angiogenesis in tumor growth and metastasis has started to redefine …

Human endothelial progenitor cells (EPCs) have been generally defined as circulating cells
that express a variety of cell surface markers similar to those expressed by vascular …

Since its inception in 2000, metronomic chemotherapy has undergone major advances as
an antiangiogenic therapy. The discovery of the pro-immune properties of chemotherapy …

It has been nearly 9years since the FDA (Food and Drug Administration) approved the first
anti-angiogenic drug (bevacizumab) for treatment of metastatic colorectal cancer. Other …

Tumor-infiltrating myeloid cells, including tumor-associated macrophages (TAMs), have
been implicated in tumor progression. We recently described a lineage of mouse monocytes …

Metronomic chemotherapy describes the close, regular administration of chemotherapy
drugs at less-toxic doses over prolonged periods of time. In 2015, the results of randomized …

Increases in the number of circulating endothelial cells (CECs) and progenitors (CEPs) have
been reported in various pathological conditions including cancer. Preclinical studies have …

Although cancer cells are not generally controlled by normal regulatory mechanisms, tumor
growth is highly dependent on the supply of oxygen, nutrients, and host-derived regulators. It …