Red blood cells as therapeutic target to treat sickle cell disease
S Bhatt, DA Argueta, K Gupta… - Antioxidants & Redox …, 2024 - liebertpub.com
Significance: Sickle cell disease (SCD) is the most common inherited diathesis affecting
mostly underserved populations globally. SCD is characterized by chronic pain and fatigue …
mostly underserved populations globally. SCD is characterized by chronic pain and fatigue …
Modulating hemoglobin allostery for treatment of sickle cell disease: current progress and intellectual property
PP Pagare, A Rastegar, O Abdulmalik… - Expert opinion on …, 2022 - Taylor & Francis
Introduction Sickle cell disease (SCD) is a debilitating inherited disorder that affects millions
worldwide. Four novel SCD therapeutics have been approved, including the hemoglobin …
worldwide. Four novel SCD therapeutics have been approved, including the hemoglobin …
Isolation and Characterisation of Quercitrin as a Potent Anti-Sickle Cell Anaemia Agent from Alchornea cordifolia
Alchornea cordifolia Müll. Arg.(commonly known as Christmas Bush) has been used
traditionally in Africa to treat sickle cell anaemia (a recessive disease, arising from the S …
traditionally in Africa to treat sickle cell anaemia (a recessive disease, arising from the S …
Targeted modification of furan‐2‐carboxaldehydes into Michael acceptor analogs yielded long‐acting hemoglobin modulators with dual antisickling activities
Sickle cell disease (SCD) is the most common genetic disorder, affecting millions of people
worldwide. Aromatic aldehydes, which increase the oxygen affinity of human hemoglobin to …
worldwide. Aromatic aldehydes, which increase the oxygen affinity of human hemoglobin to …
An investigation of structure-activity relationships of azolylacryloyl derivatives yielded potent and long-acting hemoglobin modulators for reversing erythrocyte sickling
AM Omar, O Abdulmalik, MS Ghatge, YA Muhammad… - Biomolecules, 2020 - mdpi.com
Aromatic aldehydes that bind to sickle hemoglobin (HbS) to increase the protein oxygen
affinity and/or directly inhibit HbS polymer formation to prevent the pathological hypoxia …
affinity and/or directly inhibit HbS polymer formation to prevent the pathological hypoxia …
[PDF][PDF] Isolation and Characterisation of Quercitrin, a Potent Anti-sickle Cell Anaemia Agent from the Nigerian Shrub, Alchornea Spp
OA Adeniyi - 2020 - research.aber.ac.uk
Alchornea spp. is an important plant genus in Africa, where it has been used traditionally by
healers for the treatment of sickle cell anaemia (SCA). SCA is a genetic disorder endemic to …
healers for the treatment of sickle cell anaemia (SCA). SCA is a genetic disorder endemic to …