Kinetochores are large protein assemblies that connect chromosomes to microtubules of the
mitotic and meiotic spindles in order to distribute the replicated genome from a mother cell to …

Satellite DNA represents one of the most fascinating parts of the repetitive fraction of the
eukaryotic genome. Since the discovery of highly repetitive tandem DNA in the 1960s, a lot …

The centromere is the region of the chromosome that directs its segregation in mitosis and
meiosis. Although the functional importance of the centromere has been appreciated for …

Since discovery of the centromere-specific histone H3 variant CENP-A, centromeres have
come to be defined as chromatin structures that establish the assembly site for the complex …

Genome function is dynamically regulated in part by chromatin, which consists of the
histones, non-histone proteins and RNA molecules that package DNA. Studies in …

Background Centromeres are essential for chromosome segregation, yet their DNA
sequences evolve rapidly. In most animals and plants that have been studied, centromeres …

Centromeres are the eukaryotic chromosomal sites at which the kinetochore forms and
attaches to spindle microtubules to orchestrate chromosomal segregation in mitosis and …

Much attention has been given to the idea of transgenerational epigenetic inheritance, but
fundamental questions remain regarding how much takes place and the impact that this …

The centromere performs a universally conserved function, to accurately partition genetic
information upon cell division. Yet, centromeres are among the most rapidly evolving …

In most eukaryotes, the kinetochore protein complex assembles at a single locus termed the
centromere to attach chromosomes to spindle microtubules. Holocentric chromosomes have …