Arachidonic acid-derived prostaglandins not only contribute to the development of
inflammation as intercellular pro-inflammatory mediators, but also promote the excitability of …

This review focuses on one family of the known cAMP receptors, the exchange proteins
directly activated by cAMP (EPACs), also known as the cAMP-regulated guanine nucleotide …

Chronic pain is a highly prevalent debilitating condition for which treatment options remain
limited for many patients. Ionotropic ATP signalling through excitatory and calcium …

Visceral pain (VP) is caused by internal organ disease. VP is involved in nerve conduction
and related signaling molecules, but its specific pathogenesis has not yet been fully …

Proteasomes are critical for peripheral nervous system (PNS) function. Here, we investigate
mammalian PNS proteasomes and reveal the presence of the neuronal membrane …

Chemotherapy-induced peripheral neuropathy (CIPN) is a major side effect of cancer
treatment that significantly compromises quality of life of cancer patients and survivors …

Neuropathic pain is a common clinical symptom of various diseases, and it seriously affects
the physical and mental health of patients. Owing to the complex pathological mechanism of …

The exchange proteins activated by cAMP (Epacs) have been shown to play important roles
in producing inflammation-induced nociception. Transient receptor potential vanilloid type 1 …

Gαs-coupled receptors signaling through cAMP provide a key mechanism for the
sensitization of nociceptive sensory neurons, and the cAMP effector Epac has been …

Electroacupuncture has been shown to effectively reduce chronic pain in patients with nerve
injury. The underlying mechanisms are not well understood. Accumulated evidence …