The establishment of neuronal connectivity relies on the microtubule (MT) cytoskeleton,
which provides mechanical support, roads for axonal transport and mediates signalling …

Axons are processes of neurons, up to a metre long, that form the essential biological cables
wiring nervous systems. They must survive, often far away from their cell bodies and up to a …

Microtubules are essential to neuron shape and function. Acetylation of tubulin has the
potential to directly tune the behavior and function of microtubules in cells. Although …

Alzheimer's disease (AD), the most common neurodegenerative disease and the first cause
of dementia worldwide, has no effective treatment, and its pathological mechanisms are not …

During the establishment of neural circuitry axons often need to cover long distances to
reach remote targets. The stereotyped navigation of these axons defines the connectivity …

Cytoskeletal rearrangements and crosstalk between microtubules and actin filaments are
vital for living organisms. Recently, an abundantly present microtubule polymerase, CKAP5 …

Heterozygous, missense mutations in α-or β-tubulin genes are associated with a wide range
of human brain malformations, known as tubulinopathies. We seek to understand whether a …

Axons are the narrow, up-to-meter long cellular processes of neurons that form the
biological cables wiring our nervous system. Most axons must survive for an organism's …

Regulation of microtubule dynamics by microtubule-associated proteins (MAPs) is essential
for mitotic spindle assembly and chromosome segregation. Altered microtubule dynamics …

Synapses serve as the points of communication between neurons, consisting primarily of
three components: the presynaptic membrane, synaptic cleft, and postsynaptic membrane …