Killing in the name of: T6SS structure and effector diversity

LP Allsopp, P Bernal - Microbiology, 2023 - microbiologyresearch.org
The life of bacteria is challenging, to endure bacteria employ a range of mechanisms to
optimize their environment, including deploying the type VI secretion system (T6SS). Acting …

Essential functions of chaperones and adaptors of protein secretion systems in gram‐negative bacteria

K Manera, F Kamal, B Burkinshaw… - The FEBS Journal, 2022 - Wiley Online Library
Equipped with a plethora of secreted toxic effectors, protein secretion systems are essential
for bacteria to interact with and manipulate their neighboring environment to survive in host …

Identification of type VI secretion system effector-immunity pairs using structural bioinformatics

AM Geller, M Shalom, D Zlotkin, N Blum… - Molecular Systems …, 2024 - embopress.org
The type VI secretion system (T6SS) is an important mediator of microbe–microbe and
microbe–host interactions. Gram-negative bacteria use the T6SS to inject T6SS effectors …

PAAR proteins are versatile clips that enrich the antimicrobial weapon arsenals of prokaryotes

Z Zhang, Y Liu, P Zhang, J Wang, D Li, Y Li - Msystems, 2021 - Am Soc Microbiol
Protein toxins secreted by prokaryotes have been found to affect the pathogenicity of
pathogens or directly mediate antagonistic interactions between prokaryotes. PAAR proteins …

T6SS-associated Rhs toxin-encapsulating shells: Structural and bioinformatical insights into bacterial weaponry and self-protection

CS Kielkopf, MM Shneider, PG Leiman, NMI Taylor - Structure, 2024 - cell.com
Bacteria use the type VI secretion system (T6SS) to secrete toxins into pro-and eukaryotic
cells via machinery consisting of a contractile sheath and a rigid tube. Rearrangement …

PAT: a comprehensive database of prokaryotic antimicrobial toxins

Y Liu, S Liu, Z Pan, Y Ren, Y Jiang, F Wang… - Nucleic Acids …, 2023 - academic.oup.com
Antimicrobial toxins help prokaryotes win competitive advantages in intraspecific or
interspecific conflicts and are also a critical factor affecting the pathogenicity of many …

Genome wide analysis revealed conserved domains involved in the effector discrimination of bacterial type VI secretion system

C Wang, M Chen, Y Shao, M Jiang, Q Li… - Communications …, 2023 - nature.com
Type VI secretion systems (T6SSs) deliver effectors into target cells. Besides structural and
effector proteins, many other proteins, such as adaptors, co-effectors and accessory …

T6SS accessory proteins, including DUF2169 domain-containing protein and pentapeptide repeats protein, contribute to bacterial virulence in T6SS group_5 of …

N Kim, G Han, H Jung, HH Lee, J Park, YS Seo - Plants, 2021 - mdpi.com
Burkholderia glumae are bacteria pathogenic to rice plants that cause a disease called
bacterial panicle blight (BPB) in rice panicles. BPB, induced by B. glumae, causes enormous …

A pangenomic atlas reveals that eco-evolutionary dynamics shape plant pathogen type VI secretion systems

N Aoun, SJ Georgoulis, JK Avalos, KJ Grulla, K Miqueo… - bioRxiv, 2023 - biorxiv.org
Soil-borne Ralstonia solanacearum species complex (RSSC) bacteria disrupt rhizosphere
and endophytic microbial communities as they invade roots and fatally wilt plants. RSSC …

Large-scale discovery of candidate type VI secretion effectors with antibacterial activity

AM Geller, D Zlotkin, A Levy - bioRxiv, 2021 - biorxiv.org
Type VI secretion systems (T6SS) are common bacterial contractile injection systems that
inject toxic “effector” proteins into neighboring cells. Effector discovery is generally done …