Killing in the name of: T6SS structure and effector diversity
LP Allsopp, P Bernal - Microbiology, 2023 - microbiologyresearch.org
The life of bacteria is challenging, to endure bacteria employ a range of mechanisms to
optimize their environment, including deploying the type VI secretion system (T6SS). Acting …
optimize their environment, including deploying the type VI secretion system (T6SS). Acting …
Essential functions of chaperones and adaptors of protein secretion systems in gram‐negative bacteria
Equipped with a plethora of secreted toxic effectors, protein secretion systems are essential
for bacteria to interact with and manipulate their neighboring environment to survive in host …
for bacteria to interact with and manipulate their neighboring environment to survive in host …
Identification of type VI secretion system effector-immunity pairs using structural bioinformatics
AM Geller, M Shalom, D Zlotkin, N Blum… - Molecular Systems …, 2024 - embopress.org
The type VI secretion system (T6SS) is an important mediator of microbe–microbe and
microbe–host interactions. Gram-negative bacteria use the T6SS to inject T6SS effectors …
microbe–host interactions. Gram-negative bacteria use the T6SS to inject T6SS effectors …
PAAR proteins are versatile clips that enrich the antimicrobial weapon arsenals of prokaryotes
Protein toxins secreted by prokaryotes have been found to affect the pathogenicity of
pathogens or directly mediate antagonistic interactions between prokaryotes. PAAR proteins …
pathogens or directly mediate antagonistic interactions between prokaryotes. PAAR proteins …
T6SS-associated Rhs toxin-encapsulating shells: Structural and bioinformatical insights into bacterial weaponry and self-protection
Bacteria use the type VI secretion system (T6SS) to secrete toxins into pro-and eukaryotic
cells via machinery consisting of a contractile sheath and a rigid tube. Rearrangement …
cells via machinery consisting of a contractile sheath and a rigid tube. Rearrangement …
PAT: a comprehensive database of prokaryotic antimicrobial toxins
Antimicrobial toxins help prokaryotes win competitive advantages in intraspecific or
interspecific conflicts and are also a critical factor affecting the pathogenicity of many …
interspecific conflicts and are also a critical factor affecting the pathogenicity of many …
Genome wide analysis revealed conserved domains involved in the effector discrimination of bacterial type VI secretion system
Type VI secretion systems (T6SSs) deliver effectors into target cells. Besides structural and
effector proteins, many other proteins, such as adaptors, co-effectors and accessory …
effector proteins, many other proteins, such as adaptors, co-effectors and accessory …
T6SS accessory proteins, including DUF2169 domain-containing protein and pentapeptide repeats protein, contribute to bacterial virulence in T6SS group_5 of …
N Kim, G Han, H Jung, HH Lee, J Park, YS Seo - Plants, 2021 - mdpi.com
Burkholderia glumae are bacteria pathogenic to rice plants that cause a disease called
bacterial panicle blight (BPB) in rice panicles. BPB, induced by B. glumae, causes enormous …
bacterial panicle blight (BPB) in rice panicles. BPB, induced by B. glumae, causes enormous …
A pangenomic atlas reveals that eco-evolutionary dynamics shape plant pathogen type VI secretion systems
N Aoun, SJ Georgoulis, JK Avalos, KJ Grulla, K Miqueo… - bioRxiv, 2023 - biorxiv.org
Soil-borne Ralstonia solanacearum species complex (RSSC) bacteria disrupt rhizosphere
and endophytic microbial communities as they invade roots and fatally wilt plants. RSSC …
and endophytic microbial communities as they invade roots and fatally wilt plants. RSSC …
Large-scale discovery of candidate type VI secretion effectors with antibacterial activity
AM Geller, D Zlotkin, A Levy - bioRxiv, 2021 - biorxiv.org
Type VI secretion systems (T6SS) are common bacterial contractile injection systems that
inject toxic “effector” proteins into neighboring cells. Effector discovery is generally done …
inject toxic “effector” proteins into neighboring cells. Effector discovery is generally done …