Bacterial response to oxidative stress and RNA oxidation

AF Seixas, AP Quendera, JP Sousa, AFQ Silva… - Frontiers in …, 2022 - frontiersin.org
Bacteria have to cope with oxidative stress caused by distinct Reactive Oxygen Species
(ROS), derived not only from normal aerobic metabolism but also from oxidants present in …

Reactive oxygen species (ROS)-mediated antibacterial oxidative therapies: available methods to generate ROS and a novel option proposal

S Alfei, GC Schito, AM Schito, G Zuccari - International Journal of …, 2024 - mdpi.com
The increasing emergence of multidrug-resistant (MDR) pathogens causes difficult-to-treat
infections with long-term hospitalizations and a high incidence of death, thus representing a …

[HTML][HTML] Remaining mysteries of molecular biology: the role of polyamines in the cell

L Miller-Fleming, V Olin-Sandoval, K Campbell… - Journal of molecular …, 2015 - Elsevier
The polyamines (PAs) spermidine, spermine, putrescine and cadaverine are an essential
class of metabolites found throughout all kingdoms of life. In this comprehensive review, we …

Antibiotics induce redox-related physiological alterations as part of their lethality

DJ Dwyer, PA Belenky, JH Yang… - Proceedings of the …, 2014 - National Acad Sciences
Deeper understanding of antibiotic-induced physiological responses is critical to identifying
means for enhancing our current antibiotic arsenal. Bactericidal antibiotics with diverse …

Genome-wide mapping of mutations at single-nucleotide resolution for protein, metabolic and genome engineering

AD Garst, MC Bassalo, G Pines, SA Lynch… - Nature …, 2017 - nature.com
Improvements in DNA synthesis and sequencing have underpinned comprehensive
assessment of gene function in bacteria and eukaryotes. Genome-wide analyses require …

Antimicrobial strategies centered around reactive oxygen species–bactericidal antibiotics, photodynamic therapy, and beyond

F Vatansever, WCMA de Melo, P Avci… - FEMS microbiology …, 2013 - academic.oup.com
Reactive oxygen species (ROS) can attack a diverse range of targets to exert antimicrobial
activity, which accounts for their versatility in mediating host defense against a broad range …

The role of reactive species on innate immunity

CMC Andrés, JM Pérez de la Lastra, CA Juan, FJ Plou… - Vaccines, 2022 - mdpi.com
This review examines the role of reactive species RS (of oxygen ROS, nitrogen RNS and
halogen RHS) on innate immunity. The importance of these species in innate immunity was …

The crosstalk between the gut microbiota and mitochondria during exercise

A Clark, N Mach - Frontiers in physiology, 2017 - frontiersin.org
Many physiological changes occur in response to endurance exercise in order to adapt to
the increasing energy needs, mitochondria biogenesis, increased reactive oxygen species …

Reactive oxygen species in pathogen clearance: the killing mechanisms, the adaption response, and the side effects

H Li, X Zhou, Y Huang, B Liao, L Cheng… - Frontiers in …, 2021 - frontiersin.org
Reactive oxygen species (ROS) are attractive weapons in both antibiotic-mediated killing
and host-mediated killing. However, the involvement of ROS in antibiotic-mediated killing …

Copper tolerance in bacteria requires the activation of multiple accessory pathways

A Giachino, KJ Waldron - Molecular microbiology, 2020 - Wiley Online Library
Copper is a required micronutrient for bacteria and an essential cofactor for redox‐active
cuproenzymes. Yet, excess copper is extremely toxic, and is exploited as a bacteriocide in …