In addition to ATP synthesis, mitochondria are highly dynamic organelles that modulate
apoptosis, ferroptosis, and inflammasome activation. Through executing these varied …

The transcription factor NF-E2 p45-related factor 2 (Nrf2; gene name NFE2L2) allows
adaptation and survival under conditions of stress by regulating the gene expression of …

The transcription factor Nrf2 (nuclear factor‐erythroid 2 p45‐related factor 2) functions at the
interface of cellular redox and intermediary metabolism. Nrf2 target genes encode …

Parkinson's disease (PD) is a progressive neurodegenerative disorder characterised by the
preferential loss of dopaminergic neurons in the substantia nigra. Mitochondrial dysfunction …

Mitochondrial dysfunction is associated with a spectrum of human disorders, ranging from
rare, inborn errors of metabolism to common, age-associated diseases such as …

Mitochondrial dysfunction and synaptic damage are early pathological features of the
Alzheimer's disease-affected brain. Memory impairment in Alzheimer's disease is a …

Parkinson's disease (PD) is a progressive neurodegenerative disease that causes a
debilitating movement disorder. Although most cases of PD appear to be sporadic, rare …

The key role of mitochondria in oxidative metabolism and redox homeostasis explains the
link between mitochondrial dysfunction and the development of metabolic disorders …

Mitochondrial dysfunction affects cellular energy metabolism, but less is known about the
consequences for cytoplasmic biosynthetic reactions. We report that mtDNA replication …

Hypoxia is commonly found in cancers. Hypoxia, due to the lack of oxygen (O2) as the
electron recipient, causes inefficient electron transfer through the electron transport chain at …