Diagnosis and treatment of primary aldosteronism

M Reincke, I Bancos, P Mulatero, UI Scholl… - The lancet Diabetes & …, 2021 - thelancet.com
Primary aldosteronism is a common cause of secondary hypertension associated with
excess cardiovascular morbidities. Primary aldosteronism is underdiagnosed because it …

Primary aldosteronism: state-of-the-art review

A Vaidya, GL Hundemer, K Nanba… - American Journal of …, 2022 - academic.oup.com
We are witnessing a revolution in our understanding of primary aldosteronism (PA). In the
past 2 decades, we have learned that PA is a highly prevalent syndrome that is largely …

Japan Endocrine Society clinical practice guideline for the diagnosis and management of primary aldosteronism 2021

M Naruse, T Katabami, H Shibata, M Sone… - Endocrine …, 2022 - jstage.jst.go.jp
Primary aldosteronism (PA) is associated with higher cardiovascular morbidity and mortality
rates than essential hypertension. The Japan Endocrine Society (JES) has developed an …

[11C]metomidate PET-CT versus adrenal vein sampling for diagnosing surgically curable primary aldosteronism: a prospective, within-patient trial

X Wu, R Senanayake, E Goodchild, WA Bashari… - Nature Medicine, 2023 - nature.com
Primary aldosteronism (PA) due to a unilateral aldosterone-producing adenoma is a
common cause of hypertension. This can be cured, or greatly improved, by adrenal surgery …

Accuracy of Gallium-68 Pentixafor Positron Emission Tomography–Computed Tomography for Subtyping Diagnosis of Primary Aldosteronism

J Hu, T Xu, H Shen, Y Song, J Yang, A Zhang… - JAMA Network …, 2023 - jamanetwork.com
Importance Adrenal vein sampling (AVS) is the recommended procedure for subtyping
primary aldosteronism (PA) as unilateral PA (UPA) or bilateral PA (BPA), with different …

Treating primary aldosteronism-induced hypertension: novel approaches and future outlooks

N Mullen, J Curneen, PT Donlon, P Prakash… - Endocrine …, 2024 - academic.oup.com
Primary aldosteronism (PA) is the most common cause of secondary hypertension and is
associated with increased morbidity and mortality when compared with blood pressure …

Development of [18F]AldoView as the First Highly Selective Aldosterone Synthase PET Tracer for Imaging of Primary Hyperaldosteronism

K Sander, T Gendron, KA Cybulska… - Journal of medicinal …, 2021 - ACS Publications
The purpose of this study was to synthesize a fluorine-18 labeled, highly selective
aldosterone synthase (h CYP11B2) inhibitor,[18F] AldoView, and to assess its potential for …

Identification of surgically curable primary aldosteronism by imaging in a large, multiethnic international study

GP Rossi, F Crimì, G Rossitto, L Amar… - The Journal of …, 2021 - academic.oup.com
Context Adrenal gland imaging is recommended by the current guidelines for the workup of
primary aldosteronism (PA). However, its diagnostic performance has not been established …

Feasibility of imaging-guided adrenalectomy in young patients with primary aldosteronism

GP Rossi, F Crimì, G Rossitto, L Amar, M Azizi… - …, 2022 - Am Heart Assoc
Many of the patients with primary aldosteronism (PA) are denied curative adrenalectomy
because of limited availability or failure of adrenal vein sampling. It has been suggested that …

11C-Metomidate PET-CT versus adrenal vein sampling to subtype primary aldosteronism: a prospective clinical trial

TH Puar, CM Khoo, CJ Tan, AKT Tong… - Journal of …, 2022 - journals.lww.com
Objective: Adrenal vein sampling (AVS) is recommended to subtype primary aldosteronism,
but it is technically challenging. We compared 11 C-Metomidate-PET-computed tomography …