Tens of millions of contrast-enhanced magnetic resonance imaging (MRI) exams are
performed annually around the world. The contrast agents, which improve diagnostic …

Chemical exchange saturation transfer (CEST) imaging is a relatively new magnetic
resonance imaging contrast approach in which exogenous or endogenous compounds …

Magnetic resonance imaging (MRI) has been immensely valuable in diagnostic clinical
imaging over the last few decades owing to its exceptional spatial and anatomical …

Amide proton transfer (APT) imaging is a type of chemical exchange–dependent saturation
transfer (CEST) magnetic resonance imaging (MRI) in which amide protons of endogenous …

Magnetic resonance imaging (MRI) contrast agents have become an important tool in
clinical medicine. The most common agents are Gd3+-based complexes that shorten bulk …

Multifunctional nanomedicine is emerging as a highly integrated platform that allows for
molecular diagnosis, targeted drug delivery, and simultaneous monitoring and treatment of …

Signal loss due to magnetization transfer (MT) from the macromolecular protons of biological
tissues is an important consideration for the in vivo detection of paramagnetic chemical …

Altered tissue temperature and/or pH is a common feature in pathological conditions, where
metabolic demand exceeds oxygen supply such as in tumors and following stroke …

The frequency‐encoding property of chemical exchange saturation transfer (CEST) agents
places them in a unique position among the MRI contrast agents, as it allows the …

The concept of using paramagnetic metal ion complexes as chemical exchange saturation
transfer agents (paraCEST) for molecular imaging of various biological processes first …