Cardiovascular diseases (CVDs) are the leading cause of death worldwide and represent a
major problem of public health. Over the years, life expectancy has considerably increased …

Atherosclerosis is a progressive multifaceted inflammatory disease affecting large-and
medium-sized arteries. Typical feature of this disease is the formation and build-up of …

Rationale: In patients with chronic inflammatory lung disease, pulmonary proteases can
generate neoantigens from elastin and collagen with the potential to fuel autoreactive …

The effect of cobalt on the cardiovascular system is one of many aspects of cobalt
metabolism in humans. Elastin and collagen are the main proteins of the vascular wall. The …

Elastin breakdown products are found in the serum of all human subjects. The presence of
these elastin-derived peptides (EDP) and the corresponding antibodies in circulation leads …

Thickening of the vascular basement membrane (BM) is a fundamental structural change in
the small blood vessels in diabetes. Collagen type IV (CIV) is a major component of the BMs …

Antibodies to α-elastin (elastin breakdown product) and elastin sequences devoid of cross-
linked regions (linear elastin) are found in the serum of all human subjects and correlate …

Breakdown of basement membrane is believed to be an essential step for tumor invasion
and metastasis. The interaction between tumor cells and extracellular matrix can also result …

The fibrillins are large glycoproteins components of 10-nm microfibrils found in the
extracellular matrix of most tissues. Microfibrils play a role in elastic fiber assembly and …