Mass spectrometry of nucleic acid noncovalent complexes

E Largy, A Konig, A Ghosh, D Ghosh… - Chemical …, 2021 - ACS Publications
Nucleic acids have been among the first targets for antitumor drugs and antibiotics. With the
unveiling of new biological roles in regulation of gene expression, specific DNA and RNA …

DNA folds threaten genetic stability and can be leveraged for chemotherapy

J Zell, FR Sperti, S Britton, D Monchaud - RSC Chemical Biology, 2021 - pubs.rsc.org
Damaging DNA is a current and efficient strategy to fight against cancer cell proliferation.
Numerous mechanisms exist to counteract DNA damage, collectively referred to as the DNA …

New insights into protein–DNA binding specificity from hydrogen bond based comparative study

M Lin, J Guo - Nucleic acids research, 2019 - academic.oup.com
Abstract Knowledge of protein–DNA binding specificity has important implications in
understanding DNA metabolism, transcriptional regulation and developing therapeutic …

Luminescent Cyclometalated Platinum (II) Complex Forms Emissive Intercalating Adducts with Double‐Stranded DNA and RNA: Differential Emissions and Anticancer …

T Zou, J Liu, CT Lum, C Ma, RCT Chan… - Angewandte …, 2014 - Wiley Online Library
Luminescent metallo‐intercalators are potent biosensors of nucleic acid structure and
anticancer agents targeting DNAs. There are few examples of luminescent metallo …

NBD-based fluorescent chemosensor for the selective quantification of copper and sulfide in an aqueous solution and living cells

Q Meng, Y Shi, C Wang, H Jia, X Gao… - Organic & …, 2015 - pubs.rsc.org
Chemosensors play important roles in cation and anion recognition in biological, industrial,
and environmental processes. Although many efforts have been made to develop artificial …

On the binding modes of metal NHC complexes with DNA secondary structures: implications for therapy and imaging

Ö Karaca, SM Meier-Menches, A Casini… - Chemical …, 2017 - pubs.rsc.org
Organometallic compounds currently occupy an important place in the field of medicinal
inorganic chemistry due to the unique chemical properties of metal coordination …

Luminescent platinum (II) complexes with functionalized N-heterocyclic carbene or diphosphine selectively probe mismatched and abasic DNA

SK Fung, T Zou, B Cao, T Chen, WP To, C Yang… - Nature …, 2016 - nature.com
The selective targeting of mismatched DNA overexpressed in cancer cells is an appealing
strategy in designing cancer diagnosis and therapy protocols. Few luminescent probes that …

Melting temperature measurement and mesoscopic evaluation of single, double and triple DNA mismatches

LM Oliveira, AS Long, T Brown, KR Fox, G Weber - Chemical science, 2020 - pubs.rsc.org
Unlike the canonical base pairs AT and GC, the molecular properties of mismatches such as
hydrogen bonding and stacking interactions are strongly dependent on the identity of the …

A ruthenium (II) complex as a luminescent probe for DNA mismatches and abasic sites

AN Boynton, L Marcélis, AJ McConnell… - Inorganic …, 2017 - ACS Publications
[Ru (bpy) 2 (BNIQ)] 2+(BNIQ= Benzo [c][1, 7] naphthyridine-1-isoquinoline), which
incorporates the sterically expansive BNIQ ligand, is a highly selective luminescent probe for …

NMR determination of the 2: 1 binding complex of naphthyridine carbamate dimer (NCD) and CGG/CGG triad in double-stranded DNA

T Yamada, K Furuita, S Sakurabayashi… - Nucleic Acids …, 2022 - academic.oup.com
Trinucleotide repeat (TNR) diseases are caused by the aberrant expansion of CXG (X= C, A,
G and T) sequences in genomes. We have reported two small molecules binding to TNR …