The powerful self-assembly features of DNA make it a unique template to finely organize
and control matter on the nanometre scale. While DNA alone offers a high degree of fidelity …

We set out to design, synthesize, and optimize a DNA-minimal cage capable of
encapsulating oligonucleotide drugs to facilitate their delivery. Through rational design and …

The development of nucleic acid therapeutics has been hampered by issues associated with
their stability and in vivo delivery. To address these challenges, we describe a new strategy …

Polyphosphoesters are common to both genetics and cutting-edge polymer science. This
review seeks to reframe current conceptions of the boundaries of nucleic acid and polymer …

DNA base-pairing is the central interaction in DNA assembly. However, this simple four-
letter (A–T and G–C) language makes it difficult to create complex structures without using a …

We use molecular dynamics simulations to explore concentrated solutions of semiflexible
polyelectrolyte ring polymers, akin to the DNA mini-circles, with counterions of different …

DNA origami, comprising a long folded DNA scaffold and hundreds of linear DNA staple
strands, has been developed to construct various sophisticated structures, smart devices …

The development of biocompatible drug delivery vehicles for cancer therapy in the brain
remains a big challenge. In this study, we designed self-assembled DNA nanocages …

Enormous efforts have been made to harness nanoparticles showing extravasation around
tumors for tumor-targeted drug carriers. Owing to the complexity of in vivo environments …

The use of DNA in nanobiotechnology has advanced to a stage at which almost any two or
three dimensional architecture can be designed with high precision. The choice of the DNA …