The field of single-cell omics is rapidly progressing. Although DNA and RNA sequencing-
based methods have dominated the field to date, global proteome profiling has also entered …

Simple Summary Unlike B cell malignancies, the progress on generating an adoptive T cell
therapy for relapsed/refractory acute myeloid leukemia (AML) remains insufficient. This …

Abstract Protein-Protein Interactions (PPIs) are fundamental means of functions and
signalings in biological systems. The massive growth in demand and cost associated with …

Recent studies on pediatric acute myeloid leukemia (pAML) have revealed pediatric-specific
driver alterations, many of which are underrepresented in the current classification schemas …

Background Cancer patients can achieve dramatic responses to chemotherapy yet retain
resistant tumor cells, which ultimately results in relapse. Although xenograft model studies …

Chemoresistance and relapse are the leading cause of AML-related deaths. Utilizing single-
cell RNA sequencing (scRNA-seq), we dissected the cellular states of bone marrow samples …

Inter-patient variability and the similarity of healthy and leukemic stem cells (LSCs) have
impeded the characterization of LSCs in acute myeloid leukemia (AML) and their …

Acute myeloid leukemia may be characterized by a fraction of leukemia stem cells (LSCs)
that sustain disease propagation eventually leading to relapse. Yet, the contribution of LSCs …

The BCL2 inhibitor venetoclax has recently emerged as an important component of acute
myeloid leukemia (AML) therapy. Notably, use of this agent has revealed a previously …

Targeted eradication of transformed or otherwise dysregulated cells using monoclonal
antibodies (mAb), antibody–drug conjugates (ADC), T cell engagers (TCE), or chimeric …