Regulated cell death (RCD) in cancer: key pathways and targeted therapies

F Peng, M Liao, R Qin, S Zhu, C Peng, L Fu… - Signal transduction and …, 2022 - nature.com
Regulated cell death (RCD), also well-known as programmed cell death (PCD), refers to the
form of cell death that can be regulated by a variety of biomacromolecules, which is …

Iron and chelation in biochemistry and medicine: new approaches to controlling iron metabolism and treating related diseases

GJ Kontoghiorghes, CN Kontoghiorghe - Cells, 2020 - mdpi.com
Iron is essential for all living organisms. Many iron-containing proteins and metabolic
pathways play a key role in almost all cellular and physiological functions. The diversity of …

Modular diazo compound for the bioreversible late-stage modification of proteins

JV Jun, YD Petri, LW Erickson… - Journal of the American …, 2023 - ACS Publications
We introduce a versatile strategy for the bioreversible modification of proteins. Our strategy
is based on a tricomponent molecule, synthesized in three steps, that incorporates a diazo …

Metal-binding peptides and their potential to enhance the absorption and bioavailability of minerals

TJ Ashaolu, CC Lee, JO Ashaolu, H Pourjafar… - Food chemistry, 2023 - Elsevier
Minerals including calcium, iron, zinc, magnesium, and copper have several human
nutritional functions due to their metabolic activities. Body tissues require sufficient levels of …

Naturally derived indole alkaloids targeting regulated cell death (RCD) for cancer therapy: from molecular mechanisms to potential therapeutic targets

R Qin, FM You, Q Zhao, X Xie, C Peng, G Zhan… - Journal of hematology & …, 2022 - Springer
Regulated cell death (RCD) is a critical and active process that is controlled by specific
signal transduction pathways and can be regulated by genetic signals or drug interventions …

Apoptotic proteins with non-apoptotic activity: expression and function in cancer

V Shoshan-Barmatz, T Arif, A Shteinfer-Kuzmine - Apoptosis, 2023 - Springer
Apoptosis is a process of programmed cell death in which a cell commits suicide while
maintaining the integrity and architecture of the tissue as a whole. Apoptosis involves …

Hemoglobin and cytochrome c. reinterpreting the origins of oxygenation and oxidation in erythrocytes and in vivo cancer lung cells

H Abramczyk, JM Surmacki, M Kopeć, K Jarczewska… - Scientific Reports, 2023 - nature.com
Maintaining life (respiration), cell death (apoptosis), oxygen transport and immunity are main
biological functions of heme containing proteins. These functions are controlled by the axial …

Moonlighting proteins: the case of the hexokinases

C Rodríguez-Saavedra… - Frontiers in Molecular …, 2021 - frontiersin.org
Moonlighting proteins are defined as proteins with two or more functions that are unrelated
and independent to each other, so that inactivation of one of them should not affect the …

[HTML][HTML] Metal binding proteins

EA Permyakov - Encyclopedia, 2021 - mdpi.com
Definition Metal ions play several major roles in proteins: structural, regulatory, and
enzymatic. The binding of some metal ions increase stability of proteins or protein domains …

L-serine, an endogenous amino acid, is a potential neuroprotective agent for neurological disease and injury

L Ye, Y Sun, Z Jiang, G Wang - Frontiers in Molecular Neuroscience, 2021 - frontiersin.org
Central nervous system (CNS) lesions are major causes of human death and disability
worldwide, and they cause different extents of motor and sensory dysfunction in patients …