Ketamine, a racemic mixture consisting of (S)-and (R)-ketamine, has been in clinical use
since 1970. Although best characterized for its dissociative anesthetic properties, ketamine …

The chirality of small metabolic molecules is important in controlling physiological processes
and indicating the health status of humans. Abnormal enantiomeric ratios of chiral molecules …

Ketamine, a drug introduced in the 1960s as an anesthetic agent and still used for that
purpose, has garnered marked interest over the past two decades as an emerging treatment …

Ketamine, a commonly used general anesthetic, can produce rapid and sustained
antidepressant effect. However, the efficacy and safety of the perioperative application of …

Major depressive disorder (MDD) is a chronic, recurring, and debilitating mental illness that
is the most common mood disorder in the United States. It has been almost 50 years since …

Abstract (R, S)-ketamine (ketamine) and its enantiomer (S)-ketamine (esketamine) can
produce rapid and substantial antidepressant effects. However, individual response to …

Adaptation of the nervous system to different chemical and physiologic conditions is
important for the homeostasis of brain processes and for learning and remembering …

Current pharmacotherapies for major depressive disorder (MDD) and bipolar depression
(BDep) have a distinct lag of onset that can generate great distress and impairment in …

Current therapeutic options for major depressive disorder (MDD) and bipolar disorder (BD)
are associated with a lag of onset that can prolong distress and impairment for patients, and …

D-Serine is a potent co-agonist at the NMDA glutamate receptor and has been the object of
many preclinical studies to ascertain the nature of its metabolism, its regional and cellular …