Alzheimer's disease (AD) is considered a polygenic disorder. This view is clouded, however,
by lingering uncertainty over how to treat the quasi" monogenic" role of apolipoprotein E …

The past two centuries have witnessed an unprecedented rise in human life expectancy.
Sustaining longer lives with reduced periods of disability will require an understanding of the …

Over the past decade, a growing number of studies have revealed that progressive changes
to epigenetic information accompany aging in both dividing and nondividing cells …

Aging constitutes the key risk factor for age‐related diseases such as cancer and
cardiovascular and neurodegenerative disorders. Human longevity and healthy aging are …

Although systemic diseases take the biggest toll on human health and well-being,
increasingly, a failing brain is the arbiter of a death preceded by a gradual loss of the …

What began as a National Geographic expedition, lead by Dan Buettner, to uncover the
secrets of longevity, evolved into the discovery of the 5 places around the world where …

We use a genome-wide association of 1 million parental lifespans of genotyped subjects
and data on mortality risk factors to validate previously unreplicated findings near CDKN2B …

Although antiretroviral therapy for HIV infection prevents AIDS-related complications and
prolongs life, it does not fully restore health. Long-term treated patients remain at higher than …

Here, Ruby et al. analyze an unprecedented amount of public family tree data from Ancestry
and determine that the heritability of human longevity was well below 10%, lower than the …

Human longevity is a complex phenotype with a significant familial component, yet little is
known about its genetic antecedents. Increasing evidence from animal models suggests that …