Molecular targeting therapies for neuroblastoma: Progress and challenges
There is an urgent need to identify novel therapies for childhood cancers. Neuroblastoma is
the most common pediatric solid tumor, and accounts for~ 15% of childhood cancer‐related …
the most common pediatric solid tumor, and accounts for~ 15% of childhood cancer‐related …
Neuroblastoma: developmental biology, cancer genomics and immunotherapy
NKV Cheung, MA Dyer - Nature Reviews Cancer, 2013 - nature.com
Neuroblastoma is a solid tumour that arises from the developing sympathetic nervous
system. Over the past decade, our understanding of this disease has advanced …
system. Over the past decade, our understanding of this disease has advanced …
Neuroblastoma: molecular pathogenesis and therapy
CU Louis, JM Shohet - Annual review of medicine, 2015 - annualreviews.org
Neuroblastoma is a developmental tumor of young children arising from the embryonic
sympathoadrenal lineage of the neural crest. Neuroblastoma is the primary cause of death …
sympathoadrenal lineage of the neural crest. Neuroblastoma is the primary cause of death …
Genetic predisposition to neuroblastoma
EK Barr, MA Applebaum - Children, 2018 - mdpi.com
Neuroblastoma is the most common solid tumor in children under the age of one. It displays
remarkable phenotypic heterogeneity, resulting in differences in outcomes that correlate with …
remarkable phenotypic heterogeneity, resulting in differences in outcomes that correlate with …
A focus on regulatory networks linking MicroRNAs, transcription factors and target genes in neuroblastoma
P Perri, M Ponzoni, MV Corrias, I Ceccherini… - Cancers, 2021 - mdpi.com
Simple Summary Neuroblastoma is a tumor of the sympathetic nervous system that
substantially contributes to childhood cancer mortality. Neuroblastoma originates from the …
substantially contributes to childhood cancer mortality. Neuroblastoma originates from the …
ALK is a MYCN target gene and regulates cell migration and invasion in neuroblastoma
Human anaplastic lymphoma kinase (ALK) has been identified as an oncogene that is
mutated or amplified in NBLs. To obtain a better understanding of the molecular events …
mutated or amplified in NBLs. To obtain a better understanding of the molecular events …
Midkine and Alk signaling in sympathetic neuron proliferation and neuroblastoma predisposition
T Reiff, L Huber, M Kramer, O Delattre… - …, 2011 - journals.biologists.com
Neuroblastoma (NB) is the most common extracranial solid tumor in childhood and arises
from cells of the developing sympathoadrenergic lineage. Activating mutations in the gene …
from cells of the developing sympathoadrenergic lineage. Activating mutations in the gene …
Research advances on therapeutic approaches to congenital central hypoventilation syndrome (CCHS)
S Di Lascio, R Benfante, S Cardani… - Frontiers in …, 2021 - frontiersin.org
Congenital central hypoventilation syndrome (CCHS) is a genetic disorder of
neurodevelopment, with an autosomal dominant transmission, caused by heterozygous …
neurodevelopment, with an autosomal dominant transmission, caused by heterozygous …
Developmental disorders affecting the respiratory system: CCHS and ROHHAD
I Ceccherini, KC Kurek, DE Weese-Mayer - Handbook of Clinical Neurology, 2022 - Elsevier
Abstract Rapid-onset Obesity with Hypothalamic dysfunction, Hypoventilation, and
Autonomic Dysregulation (ROHHAD) and Congenital Central Hypoventilation Syndrome …
Autonomic Dysregulation (ROHHAD) and Congenital Central Hypoventilation Syndrome …
Causative and common PHOX2B variants define a broad phenotypic spectrum
T Bachetti, I Ceccherini - Clinical Genetics, 2020 - Wiley Online Library
Abstract Paired Like homeobox 2B (PHOX2B) is a gene crucial for the differentiation of the
neural lineages of the autonomic nervous system (ANS), whose coding mutations cause …
neural lineages of the autonomic nervous system (ANS), whose coding mutations cause …