Molecular targeting therapies for neuroblastoma: Progress and challenges

A Zafar, W Wang, G Liu, X Wang, W Xian… - Medicinal research …, 2021 - Wiley Online Library
There is an urgent need to identify novel therapies for childhood cancers. Neuroblastoma is
the most common pediatric solid tumor, and accounts for~ 15% of childhood cancer‐related …

Neuroblastoma: developmental biology, cancer genomics and immunotherapy

NKV Cheung, MA Dyer - Nature Reviews Cancer, 2013 - nature.com
Neuroblastoma is a solid tumour that arises from the developing sympathetic nervous
system. Over the past decade, our understanding of this disease has advanced …

Neuroblastoma: molecular pathogenesis and therapy

CU Louis, JM Shohet - Annual review of medicine, 2015 - annualreviews.org
Neuroblastoma is a developmental tumor of young children arising from the embryonic
sympathoadrenal lineage of the neural crest. Neuroblastoma is the primary cause of death …

Genetic predisposition to neuroblastoma

EK Barr, MA Applebaum - Children, 2018 - mdpi.com
Neuroblastoma is the most common solid tumor in children under the age of one. It displays
remarkable phenotypic heterogeneity, resulting in differences in outcomes that correlate with …

A focus on regulatory networks linking MicroRNAs, transcription factors and target genes in neuroblastoma

P Perri, M Ponzoni, MV Corrias, I Ceccherini… - Cancers, 2021 - mdpi.com
Simple Summary Neuroblastoma is a tumor of the sympathetic nervous system that
substantially contributes to childhood cancer mortality. Neuroblastoma originates from the …

ALK is a MYCN target gene and regulates cell migration and invasion in neuroblastoma

MK Hasan, A Nafady, A Takatori, S Kishida, M Ohira… - Scientific reports, 2013 - nature.com
Human anaplastic lymphoma kinase (ALK) has been identified as an oncogene that is
mutated or amplified in NBLs. To obtain a better understanding of the molecular events …

Midkine and Alk signaling in sympathetic neuron proliferation and neuroblastoma predisposition

T Reiff, L Huber, M Kramer, O Delattre… - …, 2011 - journals.biologists.com
Neuroblastoma (NB) is the most common extracranial solid tumor in childhood and arises
from cells of the developing sympathoadrenergic lineage. Activating mutations in the gene …

Research advances on therapeutic approaches to congenital central hypoventilation syndrome (CCHS)

S Di Lascio, R Benfante, S Cardani… - Frontiers in …, 2021 - frontiersin.org
Congenital central hypoventilation syndrome (CCHS) is a genetic disorder of
neurodevelopment, with an autosomal dominant transmission, caused by heterozygous …

Developmental disorders affecting the respiratory system: CCHS and ROHHAD

I Ceccherini, KC Kurek, DE Weese-Mayer - Handbook of Clinical Neurology, 2022 - Elsevier
Abstract Rapid-onset Obesity with Hypothalamic dysfunction, Hypoventilation, and
Autonomic Dysregulation (ROHHAD) and Congenital Central Hypoventilation Syndrome …

Causative and common PHOX2B variants define a broad phenotypic spectrum

T Bachetti, I Ceccherini - Clinical Genetics, 2020 - Wiley Online Library
Abstract Paired Like homeobox 2B (PHOX2B) is a gene crucial for the differentiation of the
neural lineages of the autonomic nervous system (ANS), whose coding mutations cause …