Protein–protein interactions (PPIs) have pivotal roles in life processes. The studies showed
that aberrant PPIs are associated with various diseases, including cancer, infectious …

Protein–protein interactions (PPIs) are of pivotal importance in the regulation of biological
systems and are consequently implicated in the development of disease states. Recent work …

The tumour suppressor p53 is the most frequently mutated gene in human cancer, with more
than half of all human tumours carrying mutations in this particular gene. Intense efforts to …

Design of small-molecule inhibitors (MDM2 inhibitors) to block the MDM2–p53 protein–
protein interaction has been pursued as a new cancer therapeutic strategy. In recent years …

1, 2, 4-triazole is an important nucleus present in a large number of compounds. More than
thirty-five compounds containing this nucleus are introduced into the market. 1, 2, 4-triazole …

We previously reported the discovery of a class of spirooxindoles as potent and selective
small-molecule inhibitors of the MDM2–p53 interaction (MDM2 inhibitors). We report herein …

Cancer is a major devastating disease, and is a leading cause of death worldwide. Despite
the progress in cancer treatment, cancer mortality rate remains high. Therefore, the …

Abstract Blocking the MDM2/X–P53 protein–protein interaction has been widely recognized
as an attractive therapeutic strategy for the treatment of cancers. Numerous small-molecule …

Structure-based rational design led to the discovery of novel inhibitors of the MDM2–p53
protein–protein interaction. The affinity of these compounds for MDM2 was improved …

The p53 protein is the cell's principal bastion of defense against tumor‐associated DNA
damage. Commonly referred as a “guardian of the genome”, p53 is responsible for …