Cancers make their own luck: theories of cancer origins
A Jassim, EP Rahrmann, BD Simons… - Nature reviews …, 2023 - nature.com
Cancer has been a leading cause of death for decades. This dismal statistic has increased
efforts to prevent the disease or to detect it early, when treatment is less invasive, relatively …
efforts to prevent the disease or to detect it early, when treatment is less invasive, relatively …
Acinar to ductal cell trans-differentiation: A prelude to dysplasia and pancreatic ductal adenocarcinoma
Pancreatic cancer (PC) is the deadliest neoplastic epithelial malignancies and is projected
to be the second leading cause of cancer-related mortality by 2024. Five years overall …
to be the second leading cause of cancer-related mortality by 2024. Five years overall …
Cell phenotypic plasticity requires autophagic flux driven by YAP/TAZ mechanotransduction
A Totaro, Q Zhuang, T Panciera… - Proceedings of the …, 2019 - National Acad Sciences
Autophagy, besides ensuring energy metabolism and organelle renewal, is crucial for the
biology of adult normal and cancer stem cells. However, it remains incompletely understood …
biology of adult normal and cancer stem cells. However, it remains incompletely understood …
[HTML][HTML] The biophysical property of the limbal niche maintains stemness through YAP
S Bhattacharya, A Mukherjee, S Pisano… - Cell Death & …, 2023 - nature.com
The cell fate decisions of stem cells (SCs) largely depend on signals from their
microenvironment (niche). However, very little is known about how biochemical niche cues …
microenvironment (niche). However, very little is known about how biochemical niche cues …
Prdm16-mediated H3K9 methylation controls fibro-adipogenic progenitors identity during skeletal muscle repair
B Biferali, V Bianconi, DF Perez, SP Kronawitter… - Science …, 2021 - science.org
H3K9 methylation maintains cell identity orchestrating stable silencing and anchoring of
alternate fate genes within the heterochromatic compartment underneath the nuclear lamina …
alternate fate genes within the heterochromatic compartment underneath the nuclear lamina …
Biomaterial-induced conversion of quiescent cardiomyocytes into pacemaker cells in rats
Pacemaker cells can be differentiated from stem cells or transdifferentiated from quiescent
mature cardiac cells via genetic manipulation. Here we show that the exposure of rat …
mature cardiac cells via genetic manipulation. Here we show that the exposure of rat …
[HTML][HTML] Maintenance of primary hepatocyte functions in vitro by inhibiting mechanical tension-induced YAP activation
P Sun, G Zhang, X Su, C Jin, B Yu, X Yu, Z Lv, H Ma… - Cell reports, 2019 - cell.com
Hepatocytes are the primary functional cells of the liver, performing its metabolic,
detoxification, and endocrine functions. Functional hepatocytes are extremely valuable in …
detoxification, and endocrine functions. Functional hepatocytes are extremely valuable in …
Photothermal-triggered structural change of nanofiber scaffold integrating with graded mineralization to promote tendon–bone healing
C Yu, T Wang, H Diao, N Liu, Y Zhang, H Jiang… - Advanced Fiber …, 2022 - Springer
Scaffolds functionalized with graded changes in both fiber alignment and mineral content
are more appealing for tendon-bone healing. This study reports the healing of rotator cuff …
are more appealing for tendon-bone healing. This study reports the healing of rotator cuff …
Non‐genetic heterogeneity, altered cell fate and differentiation therapy
Altered capacity for self‐renewal and differentiation is a hallmark of cancer, and many
tumors are composed of cells with a developmentally immature phenotype. Among the …
tumors are composed of cells with a developmentally immature phenotype. Among the …
[HTML][HTML] Cell identity changes in ocular surface Epithelia
N Di Girolamo, M Park - Progress in Retinal and Eye Research, 2023 - Elsevier
Corneal and conjunctival epithelia arise from a common ancestral ectoderm cell, then
diverge into distinct lineages. The former develops into a multilayered stratified squamous …
diverge into distinct lineages. The former develops into a multilayered stratified squamous …