Cancer has been a leading cause of death for decades. This dismal statistic has increased
efforts to prevent the disease or to detect it early, when treatment is less invasive, relatively …

Pancreatic cancer (PC) is the deadliest neoplastic epithelial malignancies and is projected
to be the second leading cause of cancer-related mortality by 2024. Five years overall …

Autophagy, besides ensuring energy metabolism and organelle renewal, is crucial for the
biology of adult normal and cancer stem cells. However, it remains incompletely understood …

The cell fate decisions of stem cells (SCs) largely depend on signals from their
microenvironment (niche). However, very little is known about how biochemical niche cues …

H3K9 methylation maintains cell identity orchestrating stable silencing and anchoring of
alternate fate genes within the heterochromatic compartment underneath the nuclear lamina …

Pacemaker cells can be differentiated from stem cells or transdifferentiated from quiescent
mature cardiac cells via genetic manipulation. Here we show that the exposure of rat …

Hepatocytes are the primary functional cells of the liver, performing its metabolic,
detoxification, and endocrine functions. Functional hepatocytes are extremely valuable in …

Scaffolds functionalized with graded changes in both fiber alignment and mineral content
are more appealing for tendon-bone healing. This study reports the healing of rotator cuff …

Altered capacity for self‐renewal and differentiation is a hallmark of cancer, and many
tumors are composed of cells with a developmentally immature phenotype. Among the …

Corneal and conjunctival epithelia arise from a common ancestral ectoderm cell, then
diverge into distinct lineages. The former develops into a multilayered stratified squamous …