The lung is a primary organ for gas exchange in mammals that represents the largest
epithelial surface in direct contact with the external environment. It also serves as a crucial …

Clear cell renal cell carcinomas (ccRCCs) are highly immune infiltrated, but the effect of
immune heterogeneity on clinical outcome in ccRCC has not been fully characterized. Here …

Alzheimer's disease (AD) is characterized by the accumulation of amyloid-β and tau. We
previously reported that administration of bone marrow mesenchymal stem cells (BM-MSCs) …

Excessive production of inflammatory chemokines can cause chronic inflammation and thus
impair cutaneous wound healing. Capturing chemokine signals using wound dressing …

Gene targeting in mice (transgenic and knockout) has provided investigators with an
unparalleled armamentarium in recent decades to dissect the cellular and molecular basis …

Poly (ethylene oxide)(PEO) and poloxamers, a class of poly (ethylene oxide)-b-poly
(propylene oxide)-b-poly (ethylene oxide)(PEO-PPO-PEO) triblock copolymers, have many …

Leukocytes sense extracellular ATP, a danger-associated molecular pattern, released
during cellular stress and death, via activation of cell surface P2X and P2Y receptors. Here …

Neutrophilic airway inflammation is a hallmark of patients with severe asthma. Although we
have reported that both IL-33 and IL-17A contributed to IgE-mediated neutrophilic …

Respirovirus such as influenza virus infection induces pulmonary anti-viral immune
response, orchestration of innate and adaptive immunity restrain viral infection, otherwise …

Functional immune responses are increasingly important for clinical studies, providing in
depth biomarker information to assess immunotherapy or vaccination. Incorporating …