Tumorigenesis is highly correlated with the accumulation of mutations. The abundant and
extensive DNA oxidation product, 8-Oxoguanine (8-oxoG), can cause mutations if it is not …

Unlike normal tissues, tumor cells possess a propensity for genomic instability, resulting
from elevated oxidant levels produced by oncogenic signaling and aberrant cellular …

Abstract β-Carotene, as a kind of potent antioxidant compounds, has gained extensive
attention. Blakeslea trispora, a filiform aerobic fungus, has been proposed as a natural …

Acute myeloid leukemia (AML) is an aggressive hematologic malignancy, exhibiting high
levels of reactive oxygen species (ROS). ROS levels have been suggested to drive …

MTH1 helps prevent misincorporation of ROS-damaged dNTPs into genomic DNA; however,
there is little understanding of how MTH1 itself is regulated. Here, we report that MTH1 is …

Karonudib (TH1579) is a novel compound that exerts anti-tumor activities and has recently
entered phase I clinical testing. The aim of this study was to conduct a pre-clinical trial in …

There is an unmet need for new antimitotic drug combinations that target cancer-specific
vulnerabilities. Based on our finding of elevated biomolecule oxidation in mitotically arrested …

Abstract MutT Homolog 1 (MTH1) is a mammalian 8-oxodGTPase for sanitizing oxidative
damage to the nucleotide pool. Nudix type 5 (NUDT5) also sanitizes 8-oxodGDP in the …

Glioblastoma multiforme (GBM) is an aggressive form of brain cancer with poor prognosis.
Cancer cells are characterized by a specific redox environment that adjusts metabolism to its …

Reactive oxygen species (ROS) oxidize nucleotide triphosphate pools (eg, 8-oxodGTP),
which may kill cells if incorporated into DNA. Whether cancers avoid poisoning from …