Opioid receptors: drivers to addiction?
E Darcq, BL Kieffer - Nature Reviews Neuroscience, 2018 - nature.com
Drug addiction is a worldwide societal problem and public health burden, and results from
recreational drug use that develops into a complex brain disorder. The opioid system, one of …
recreational drug use that develops into a complex brain disorder. The opioid system, one of …
Dopamine and glucose, obesity, and reward deficiency syndrome
Obesity as a result of overeating as well as a number of well described eating disorders has
been accurately considered to be a world-wide epidemic. Recently a number of theories …
been accurately considered to be a world-wide epidemic. Recently a number of theories …
Endogenous opiates and behavior: 2014
RJ Bodnar - Peptides, 2016 - Elsevier
This paper is the thirty-seventh consecutive installment of the annual review of research
concerning the endogenous opioid system. It summarizes papers published during 2014 …
concerning the endogenous opioid system. It summarizes papers published during 2014 …
Hatching the behavioral addiction egg: Reward Deficiency Solution System (RDSS)™ as a function of dopaminergic neurogenetics and brain functional connectivity …
K Blum, M Febo, T McLaughlin, FJ Cronje… - Journal of Behavioral …, 2014 - akjournals.com
Background Following the first association between the dopamine D2 receptor gene
polymorphism and severe alcoholism, there has been an explosion of research reports in …
polymorphism and severe alcoholism, there has been an explosion of research reports in …
Nicotine reinforcement in never-smokers
AN Duke, MW Johnson, CJ Reissig, RR Griffiths - Psychopharmacology, 2015 - Springer
Rationale Global tobacco-related mortality dwarfs that of all other drugs. Nicotine is believed
to be the primary agent responsible for tobacco use and addiction. However, nicotine is a …
to be the primary agent responsible for tobacco use and addiction. However, nicotine is a …
Testing familial transmission of smoking with two different research designs
Introduction Classical twin studies show that smoking is heritable. To determine if shared
family environment plays a role in addition to genetic factors, and if they interact (G× E), we …
family environment plays a role in addition to genetic factors, and if they interact (G× E), we …
A gene-by-sex interaction for nicotine reward: evidence from humanized mice and epidemiology
RE Bernardi, K Zohsel, N Hirth, J Treutlein… - Translational …, 2016 - nature.com
It has been proposed that vulnerability to nicotine addiction is moderated by variation at the
μ-opioid receptor locus (OPRM1), but results from human studies vary and prospective …
μ-opioid receptor locus (OPRM1), but results from human studies vary and prospective …
Parental smoke exposure and the development of nicotine craving in adolescent novice smokers: the roles of DRD2, DRD4, and OPRM1 genotypes
Background Among adolescent novice smokers, craving is often the first, and is the most
reported, symptom of nicotine dependence. Until now, little has been known about the …
reported, symptom of nicotine dependence. Until now, little has been known about the …
Associations between initial subjective experiences with tobacco and self-reported recent use in young adulthood
Background: Youth tobacco use behaviors are predictive of patterns in adulthood and effect
long-term health outcomes. Yet, few studies have examined the effect of initial subjective …
long-term health outcomes. Yet, few studies have examined the effect of initial subjective …
Significant association of mu-opioid receptor 1 haplotype with tobacco smoking in healthy control subjects but not in patients with schizophrenia and alcohol …
Tobacco smoking is highly prevalent in patients with schizophrenia and alcohol
dependence. The underlying neurobiology of nicotine addiction is complex. Rewarding …
dependence. The underlying neurobiology of nicotine addiction is complex. Rewarding …