RNA modifications have recently emerged as critical posttranscriptional regulators of gene
expression programmes. Significant advances have been made in understanding the …

Ribosomes are a complex ensemble of rRNA and ribosomal proteins that function as mRNA
translation machines. Ribosome biogenesis is a multistep process that begins in the …

Functional characterization of pseudouridine (Ψ) in mammalian mRNA has been hampered
by the lack of a quantitative method that maps Ψ in the whole transcriptome. We report …

The assembly of ribosomal subunits is a highly orchestrated process that involves a huge
cohort of accessory factors. Most eukaryotic ribosome biogenesis factors were first identified …

Cancer is one of the major diseases threatening human life and health worldwide.
Epigenetic modification refers to heritable changes in the genetic material without any …

The conceptual origins of ribosome specialization can be traced back to the earliest days of
molecular biology. Yet, this field has only recently begun to gather momentum, with …

Cellular senescence is an irreversible state of cell-cycle arrest induced by various stresses,
including aberrant oncogene activation, telomere shortening, and DNA damage. Through a …

One of the most critical steps of protein synthesis is coupled translocation of messenger
RNA (mRNA) and transfer RNAs (tRNAs) required to advance the mRNA reading frame by …

Covering: from 2000 up to the very early part of 2023 S-Adenosyl-L-methionine (SAM) is a
naturally occurring trialkyl sulfonium molecule that is typically associated with biological …

The selection of an open reading frame (ORF) for translation of eukaryotic mRNA relies on
remodeling of the scanning 48S initiation complex into an elongation-ready 80S ribosome …