Tau biomarkers in dementia: positron emission tomography radiopharmaceuticals in tauopathy assessment and future perspective

M Ricci, A Cimini, R Camedda, A Chiaravalloti… - International Journal of …, 2021 - mdpi.com
Abnormal accumulation of Tau protein is closely associated with neurodegeneration and
cognitive impairment and it is a biomarker of neurodegeneration in the dementia field …

A critical review of radiotracers in the positron emission tomography imaging of traumatic brain injury: FDG, tau, and amyloid imaging in mild traumatic brain injury and …

C Ayubcha, ME Revheim, A Newberg… - European Journal of …, 2021 - Springer
Purpose Positron emission tomography (PET) has been widely utilized in the study of
traumatic brain injury (TBI) for decades. While most applications of PET have attempted to …

In vivo tau pathology is associated with synaptic loss and altered synaptic function

EM Coomans, DN Schoonhoven, H Tuncel… - Alzheimer's research & …, 2021 - Springer
Background The mechanism of synaptic loss in Alzheimer's disease is poorly understood
and may be associated with tau pathology. In this combined positron emission tomography …

A head-to-head comparison between plasma ptau181 and tau pet along the Alzheimer's disease continuum

EM Coomans, IMW Verberk… - Journal of Nuclear …, 2023 - Soc Nuclear Med
Both plasma tau phosphorylated at threonine-181 (pTau181) and tau PET show potential for
detecting Alzheimer's disease (AD) pathology and predicting clinical progression. In this …

Associations between quantitative [18F]flortaucipir tau PET and atrophy across the Alzheimer's disease spectrum

T Timmers, R Ossenkoppele, EE Wolters… - Alzheimer's research & …, 2019 - Springer
Background Neuropathological studies have linked tau aggregates to neuronal loss. To
describe the spatial distribution of neurofibrillary tangle pathology in post-mortem tissue …

Genetically identical twins show comparable tau PET load and spatial distribution

EM Coomans, J Tomassen, R Ossenkoppele… - Brain, 2022 - academic.oup.com
Tau accumulation starts during the preclinical phase of Alzheimer's disease and is closely
associated with cognitive decline. For preventive purposes, it is important to identify factors …

Tau pathology and relative cerebral blood flow are independently associated with cognition in Alzheimer's disease

D Visser, EE Wolters, SCJ Verfaillie… - European journal of …, 2020 - Springer
Purpose We aimed to investigate associations between tau pathology and relative cerebral
blood flow (rCBF), and their relationship with cognition in Alzheimer's disease (AD), by using …

Performance of a [18F]Flortaucipir PET Visual Read Method Across the Alzheimer Disease Continuum and in Dementia With Lewy Bodies

EM Coomans, LA De Koning, RM Rikken… - Neurology, 2023 - AAN Enterprises
Background and Objectives Recently, the US Food and Drug Administration approved the
tau-binding radiotracer [18F] flortaucipir and an accompanying visual read method to …

[18F]Flortaucipir PET Across Various MAPT Mutations in Presymptomatic and Symptomatic Carriers

EE Wolters, JM Papma, SCJ Verfaillie, D Visser… - Neurology, 2021 - AAN Enterprises
Objective To assess the [18F] flortaucipir binding distribution across MAPT mutations in
presymptomatic and symptomatic carriers. Methods We compared regional [18F] flortaucipir …

Test–retest repeatability of [18F]Flortaucipir PET in Alzheimer's disease and cognitively normal individuals

T Timmers, R Ossenkoppele, D Visser… - Journal of Cerebral …, 2020 - journals.sagepub.com
The aim of this study was to investigate the test–retest (TRT) repeatability of various
parametric quantification methods for [18F] Flortaucipir positron emission tomography (PET) …