Biochemical, physiological and medical aspects of ubiquinone function

L Ernster, G Dallner - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 1995 - Elsevier
This presentation is a brief review of current knowledge concerning some biochemical,
physiological and medical aspects of the function of ubiquinone (coenzyme Q) in …

Experimental and clinical basis for the use of statins in patients with ischemic and nonischemic cardiomyopathy

K Ramasubbu, J Estep, DL White, A Deswal… - Journal of the American …, 2008 - jacc.org
Over the past 2 decades our understanding of the pathologic mechanisms that lead to heart
failure (HF) has evolved from simplistic hemodynamic models to more complex models that …

Evidence of drug–nutrient interactions with chronic use of commonly prescribed medications: An update

ES Mohn, HJ Kern, E Saltzman, SH Mitmesser… - Pharmaceutics, 2018 - mdpi.com
The long-term use of prescription and over-the-counter drugs can induce subclinical and
clinically relevant micronutrient deficiencies, which may develop gradually over months or …

Ubiquinone: cholesterol's reclusive cousin

IP Hargreaves - Annals of clinical biochemistry, 2003 - journals.sagepub.com
Coenzyme Q10 (CoQ10) is the predominant form of ubiquinone in man. CoQ10 functions as
an electron carrier in the mitochondrial respiratory chain as well as serving as an important …

Squalene epoxidase as hypocholesterolemic drug target revisited

A Chugh, A Ray, JB Gupta - Progress in Lipid Research, 2003 - Elsevier
Therapeutic success of statins has distinctly established inhibition of de novo hepatic
cholesterol synthesis as an effective approach to lower plasma LDL-cholesterol, the major …

Lipid-lowering drugs (statins), cholesterol, and coenzyme Q10. The Baycol case--a modern Pandora's box.

EG Bliznakov - Biomedicine & Pharmacotherapy= Biomedecine & …, 2002 - europepmc.org
Lipid-lowering drugs (statins), cholesterol, and coenzyme Q10. The Baycol case--a modern
Pandora's box. - Abstract - Europe PMC Sign in | Create an account https://orcid.org Europe …

Active isoprenoid pathway in the intra-erythrocytic stages of Plasmodium falciparum: presence of dolichols of 11 and 12 isoprene units

AS Couto, EA Kimura, VJ Peres, ML Uhrig… - Biochemical …, 1999 - portlandpress.com
N-glycosylation of proteins is required for the intra-erythrocytic schizogony of Plasmodium
falciparum. In eukaryotic cells, this process involves the transfer of oligosaccharides from a …

Statins and neuroprotection: basic pharmacology needed

WG Wood, WE Mΰller, GP Eckert - Molecular neurobiology, 2014 - Springer
Statins are attracting great interest albeit with some controversy in treating certain
neurodegenerative diseases such as Alzheimer disease, Parkinson disease, multiple …

Statins and modulation of oxidative stress

J Beltowski - Toxicology mechanisms and methods, 2005 - Taylor & Francis
Statins inhibit the activity of a rate-limiting enzyme in cholesterol biosynthesis, converting 3-
hydroxy 3-methylglutaryl coenzyme A to mevalonate, and are widely used in the treatment of …

[HTML][HTML] Ubiquinone supplementation during lovastatin treatment: effect on LDL oxidation ex vivo

A Palomäki, K Malminiemi, T Solakivi… - Journal of lipid …, 1998 - Elsevier
A randomized, double-masked, placebo-controlled cross-over trial was carried out to
evaluate whether ubiquinone supplementation (180 mg daily) corrects impaired defence …