Three-dimensional cardiac computational modelling: methods, features and applications

A Lopez-Perez, R Sebastian, JM Ferrero - Biomedical engineering online, 2015 - Springer
The combination of computational models and biophysical simulations can help to interpret
an array of experimental data and contribute to the understanding, diagnosis and treatment …

Efficient probabilistic model personalization integrating uncertainty on data and parameters: Application to eikonal-diffusion models in cardiac electrophysiology

E Konukoglu, J Relan, U Cilingir, BH Menze… - Progress in biophysics …, 2011 - Elsevier
Biophysical models are increasingly used for medical applications at the organ scale.
However, model predictions are rarely associated with a confidence measure although there …

Numerical approximation of parametrized problems in cardiac electrophysiology by a local reduced basis method

S Pagani, A Manzoni, A Quarteroni - Computer Methods in Applied …, 2018 - Elsevier
The efficient solution of coupled PDEs/ODEs problems arising in cardiac electrophysiology
is of key importance whenever interested to study the electrical behavior of the tissue for …

Personalization of atrial anatomy and electrophysiology as a basis for clinical modeling of radio-frequency ablation of atrial fibrillation

MW Krueger, G Seemann, K Rhode… - IEEE transactions on …, 2012 - ieeexplore.ieee.org
Multiscale cardiac modeling has made great advances over the last decade. Highly detailed
atrial models were created and used for the investigation of initiation and perpetuation of …

Simultaneous data assimilation and cardiac electrophysiology model correction using differentiable physics and deep learning

V Kashtanova, M Pop, I Ayed, P Gallinari… - Interface …, 2023 - royalsocietypublishing.org
Modelling complex systems, like the human heart, has made great progress over the last
decades. Patient-specific models, called 'digital twins', can aid in diagnosing arrhythmias …

Automated framework for the inclusion of a his–purkinje system in cardiac digital twins of ventricular electrophysiology

K Gillette, MAF Gsell, J Bouyssier, AJ Prassl… - Annals of biomedical …, 2021 - Springer
Personalized models of cardiac electrophysiology (EP) that match clinical observation with
high fidelity, referred to as cardiac digital twins (CDTs), show promise as a tool for tailoring …

Whole heart detailed and quantitative anatomy, myofibre structure and vasculature from X-ray phase-contrast synchrotron radiation-based micro computed …

A Gonzalez-Tendero, C Zhang… - European Heart …, 2017 - academic.oup.com
Background While individual cardiac myocytes only have a limited ability to shorten, the
heart efficiently pumps a large volume-fraction thanks to a cell organization in a complex 3D …

Physics-constrained deep learning for robust inverse ecg modeling

J Xie, B Yao - IEEE Transactions on Automation Science and …, 2022 - ieeexplore.ieee.org
The rapid development in advanced sensing and imaging brings about a data-rich
environment, facilitating the effective modeling, monitoring, and control of complex systems …

[HTML][HTML] Images as drivers of progress in cardiac computational modelling

P Lamata, R Casero, V Carapella, SA Niederer… - Progress in biophysics …, 2014 - Elsevier
Computational models have become a fundamental tool in cardiac research. Models are
evolving to cover multiple scales and physical mechanisms. They are moving towards …

Improving cardiomyocyte model fidelity and utility via dynamic electrophysiology protocols and optimization algorithms

T Krogh‐Madsen, EA Sobie… - The Journal of …, 2016 - Wiley Online Library
Mathematical models of cardiac electrophysiology are instrumental in determining
mechanisms of cardiac arrhythmias. However, the foundation of a realistic multiscale heart …