Structure, function, and pharmacology of glutamate receptor ion channels
Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …
Structure, function, and allosteric modulation of NMDA receptors
NMDA-type glutamate receptors are ligand-gated ion channels that mediate a Ca2+-
permeable component of excitatory neurotransmission in the central nervous system (CNS) …
permeable component of excitatory neurotransmission in the central nervous system (CNS) …
The origin of NMDA receptor hypofunction in schizophrenia
K Nakazawa, K Sapkota - Pharmacology & therapeutics, 2020 - Elsevier
Abstract N-methyl-d-aspartate (NMDA) receptor (NMDAR) hypofunction plays a key role in
pathophysiology of schizophrenia. Since NMDAR hypofunction has also been reported in …
pathophysiology of schizophrenia. Since NMDAR hypofunction has also been reported in …
NMDA receptors in the central nervous system
NMDA-type glutamate receptors are ligand-gated ion channels that mediate a major
component of excitatory neurotransmission in the central nervous system (CNS). They are …
component of excitatory neurotransmission in the central nervous system (CNS). They are …
Amantadine inhibits NMDA receptors by accelerating channel closure during channel block
TA Blanpied, RJ Clarke, JW Johnson - Journal of Neuroscience, 2005 - Soc Neuroscience
The channel of NMDA receptors is blocked by a wide variety of drugs. NMDA receptor
channel blockers include drugs of abuse that induce psychotic behavior, such as …
channel blockers include drugs of abuse that induce psychotic behavior, such as …
Kinetics of Mg2+ unblock of NMDA receptors: implications for spike‐timing dependent synaptic plasticity
The time course of Mg2+ block and unblock of NMDA receptors (NMDARs) determines the
extent they are activated by depolarization. Here, we directly measure the rate of NMDAR …
extent they are activated by depolarization. Here, we directly measure the rate of NMDAR …
Disease-associated missense mutations in GluN2B subunit alter NMDA receptor ligand binding and ion channel properties
Genetic and bioinformatic analyses have identified missense mutations in GRIN2B encoding
the NMDA receptor GluN2B subunit in autism, intellectual disability, Lennox Gastaut and …
the NMDA receptor GluN2B subunit in autism, intellectual disability, Lennox Gastaut and …
Breakdown of effective connectivity during slow wave sleep: investigating the mechanism underlying a cortical gate using large-scale modeling
Effective connectivity between cortical areas decreases during slow wave sleep. This
decline can be observed in the reduced interareal propagation of activity evoked either …
decline can be observed in the reduced interareal propagation of activity evoked either …
Potassium, sodium, calcium and glutamate‐gated channels: pore architecture and ligand action
BS Zhorov, DB Tikhonov - Journal of neurochemistry, 2004 - Wiley Online Library
In the last decade, the idea of common organization of certain ion channel families
exhibiting diverse physiological and pharmacological properties has received strong …
exhibiting diverse physiological and pharmacological properties has received strong …
[HTML][HTML] Molecular rearrangements of the extracellular vestibule in NMDAR channels during gating
AI Sobolevsky, C Beck, LP Wollmuth - Neuron, 2002 - cell.com
Many N-methyl-D-aspartate receptor (NMDAR) channel blockers that have therapeutic
potential can be trapped in the closed state. Using a combination of the substituted cysteine …
potential can be trapped in the closed state. Using a combination of the substituted cysteine …