Bone's remarkable mechanical properties are a result of its hierarchical structure. The
mineralized collagen fibrils, made up of collagen fibrils and crystal platelets, are bone's …

With the increasing demand for novel bone repair solutions that overcome the drawbacks of
current grafting techniques, the design of artificial bone scaffolds is a central focus in bone …

Although musculoskeletal diseases such as osteoporosis are diagnosed and treatment
outcome is evaluated based mainly on routine clinical outcomes of bone mineral density …

The purpose of this narrative review was to discuss the scientific milestones that led to the
current understanding of the root dentinal microcrack phenomenon based on the interplay …

Osteocytes can resorb as well as replace bone adjacent to the expansive lacunar-
canalicular system (LCS). Suppressed LCS remodeling decreases bone fracture toughness …

Abstract Purpose of Review In perilacunar/canalicular remodeling (PLR), osteocytes
dynamically resorb, and then replace, the organic and mineral components of the …

Visualizing bone mineralization and collagen fibril organization at intermediate scales
between the nanometer and the hundreds of microns range, is still an important challenge …

Osteocytes are involved in mechanosensation and mechanotransduction in bone and
hence, are key to bone adaptation in response to development, ageing and disease. Thus …

Advances in single-cell technologies have transformed the ability to identify the individual
cell types present within tissues and organs. The musculoskeletal bionetwork, part of the …

The osteocyte lacuno-canalicular network (LCN) is essential for bone remodeling because
osteocytes regulate cell recruitment. This has been proposed to occur through liquid-flow …