Introduction: Orally administered small molecule kinase inhibitors (KI) are a key class of
targeted anti-cancer medicines that have contributed substantially to improved survival …

Abstract Tyrosine Kinase Inhibitors (TKIs) represent a pharmacological category of targeted
therapeutics deployed for the treatment of malignant pathologies. Considering the side …

Therapeutic drug monitoring (TDM) has shown to benefit patients treated with drugs of many
drug classes, among which is oncology. With an increasing demand for drug monitoring …

Kinase inhibitors (KIs) and antiandrogen drugs (AAs) are oral anticancer drugs with narrow
therapeutic index that exhibit high inter-and intra-individual variability. We describe here a …

Green tea (GT) is one of the most consumed beverages worldwide. Tyrosine kinase
inhibitors (TKIs) belong to the oral targeted therapy that gained much interest in oncology …

Objectives: Dabrafenib is used as an active pharmaceutical ingredient acts as an inhibitor of
the associated enzyme B-Raf, which plays a role in the regulation of cell growth. In the …

Electrochemical properties of regorafenib (REG) were studied in 0.1 M Britton− Robinson
buffer-methanol solutions (3: 2, v/v) with pH between 3 and 8 at carbon paste electrode by …

Lapatinib is an anticancer used for treatment of the patients with advanced metastatic breast
cancer in conjunction with the chemotherapy drug capecitabine or with letrozole for the …

Background: Routine therapeutic drug monitoring is a promising approach for the rational
use of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) and …

This study describes, for the first time, the experimental and computational investigations for
evaluation of kolliphor RH 40 as a fluorescence enhancer surfactant in development of a …