RNA splicing represents a post-transcriptional mechanism to generate multiple functional
RNAs or proteins from a single transcript. The evolution of RNA splicing is a prime example …

Alcohol consumption is increasing worldwide. Many child‐bearing‐aged women consume
alcohol during pregnancy, intentionally or unintentionally, thereby increasing the potential …

Bicuspid aortic valve (BAV) is a heritable congenital heart defect and an important risk factor
for valvulopathy and aortopathy. Here we report a genome-wide association scan of 466 …

Background Several genes encoding transcription factors are known to be the primary
cause of congenital heart disease. NKX2‐5 and GATA4 were the first congenital heart …

The septation defect is one of the main categories of congenital heart disease (CHD). They
can affect the septation of the atria leading to atrial septal defect (ASD), septation of …

Abstract NKX2. 5, a homeobox containing gene, plays an important role in embryonic heart
development and associated mutations are linked with various cardiac abnormalities. We …

Accumulating evidence has suggested a link between maternal di‐(2‐ethylhexyl)‐phthalate
(DEHP) exposure and various developmental abnormalities. However, the evidence …

Transcription factor GATA4 is known to play crucial role during heart development,
regulating expression of several other key cardiogenic factors. Various GATA4 mutations are …

Synonymous variations, previously considered as neutral, are recently shown to have a
significant impact on mRNA structure and stability thereby affecting protein expression and …

Background The aim of the present study was to investigate the role of microRNA (miRNA)
let-7a in down-regulation of β 1-adrenoceptors (β 1-AR) and elucidate the underlying …