Human skin is the largest organ of the body and is an effective physical barrier keeping it
from environmental conditions. This barrier function of the skin is based on stratum corneum …

The barrier functions of skin against water loss, microbial invasion and penetration of
xenobiotics rely, in part, on the spatial distribution of the biomolecular constituents in the skin …

As the most voluminous organ of the body that is exposed to the outer environment, the skin
suffers from both intrinsic and extrinsic aging factors. Skin aging is characterized by features …

Restoring the lipid homeostasis of the stratum corneum (SC) is a common strategy to
enhance skin barrier function. Here, we used a ceramide containing vernix caseosa (VC) …

Deficiency or altered composition of stratum corneum (SC) lipids such as ceramides (CERs),
causing skin barrier dysfunction and skin dryness, have been associated with skin diseases …

The aim of this randomized controlled trial was to assess the efficacy of a cream containing
ceramides and magnesium (Cer-Mg) in the treatment of mild to moderate atopic dermatitis …

Introduction: Atopic dermatitis is a chronic, relapsing, pruritic inflammatory skin disease. Both
skin barrier defects and abnormal immune reactions contribute to this complex disease …

Objective Xerosis is a serious problem among the very old. It is a dermatological challenge
caused by significant alterations in stratum corneum (SC) function and structure. Two …

Disrupted skin barrier, one of the severe attributes of inflammatory skin diseases, is caused
by lower content and pathological changes of lipids in the uppermost skin layer—stratum …

Background Peroxisome proliferator-activated receptors (PPARs) govern epidermal lipid
synthesis and metabolism. In skin, PPAR activation has been shown to regulate genes …