Cellular theory of aging states that human aging is the result of cellular aging, in which an
increasing proportion of cells reach senescence. Senescence, from the Latin word senex …

The function of p53 as a tumour suppressor has been attributed to its ability to promote cell
death or permanently inhibit cell proliferation. However, in recent years, it has become clear …

Intrinsically disordered proteins (IDPs) do not have rigid 3D structures, showing changes in
their folding depending on the environment or ligands. Intrinsically disordered proteins are …

In this article, we review signal transduction pathways through which acupuncture treats
nervous system diseases. We electronically searched the databases, including PubMed …

Cell fate decisions are critical for life, yet little is known about how their reliability is achieved
when signals are noisy and fluctuating with time. In this study, we show that in budding …

The PI3K/AKT signaling pathway plays a role in most cellular functions linked to cancer
progression, including cell growth, proliferation, cell survival, tissue invasion and …

To assess the potential of intrinsically disordered proteins (IDPs) as drug design targets, we
have analyzed the ligand‐binding cavities of two datasets of IDPs (containing 37 and 16 …

Developing pharmacological strategies for controlling ionizing radiation (IR)-induced cell
death is important for both mitigating radiation damage and alleviating the side effects of anti …

The tumor suppressor p53 protein shows various dynamic responses depending on the
types and extent of cellular stresses. In particular, in response to DNA damage induced by γ …

Cells losing the ability to self-regulate in response to damage are a hallmark of cancer.
When a cell encounters damage, regulatory pathways estimate the severity of damage and …