Major depressive disorder (MDD) is characterized by persistent depressed mood, loss of
interest or pleasure in previously enjoyable activities, recurrent thoughts of death, and …

Depression predisposes to medical illnesses and advances biological aging indicated by
shorter telomere length, accelerated brain aging and advanced epigenetic aging. Medical …

Background The benefits and risks of augmenting or switching antidepressants in older
adults with treatment-resistant depression have not been extensively studied. Methods We …

The world's population is aging, bringing about an ever‐greater burden of mental disorders
in older adults. Given multimorbidities, the mental health care of these people and their …

Importance Treatment-resistant depression (TRD) is common in older adults. Bilateral
repetitive transcranial magnetic stimulation (rTMS) of the dorsolateral prefrontal cortex for 48 …

Importance Depression in older adults is a common psychiatric disorder affecting their
health-related quality of life. Major depression occurs in 2% of adults aged 55 years or older …

Background Elderly patients with major depression have a poorer prognosis, are less
responsive to treatment, and show greater functional decline compared with younger …

Cytokines have been implicated in the pathology of depression. Currently, the evidence is
based on cross-sectional studies and meta-analytic research comparing blood …

Objectives To provide a succinct, clinically useful summary of the management of bipolar
disorder, based on the 2020 Royal Australian and New Zealand College of Psychiatrists …

Late-life depression occurring in older adults is common, recurrent, and malignant. It is
characterized by affective symptoms, but also cognitive decline, medical comorbidity, and …