Within the canonical repertoire of the amino acid involved in protein biogenesis, proline
plays a unique role as an amino acid presenting a modified backbone rather than a side …

The 3D structure and surface characteristics of proteins and peptides are crucial for
interactions with receptors or ligands and can be modified to some extent to modulate their …

Hydroxylation and fluorination of proline alters the pyrrolidine ring pucker and the trans: cis
amide bond ratio in a stereochemistry-dependent fashion, affecting molecular recognition of …

Perfluorocarbons, saturated carbon chains in which all the hydrogen atoms are replaced
with fluorine, form a separate phase from both organic and aqueous solutions. Though …

The peptide bond formation with the amino acid proline (Pro) on the ribosome is slow,
resulting in translational stalling when several Pro have to be incorporated into the peptide …

Side chain-fluorinated amino acids are useful tools in medicinal chemistry and protein
science. In this review, we outline some general strategies for incorporating fluorine atom (s) …

Amide bonds at the proline nitrogen are particularly susceptible to rotation, affording cis and
trans isomers. Installation of a stereochemically defined electron-withdrawing fluorine atom …

In the context of drug discovery, novel spirocyclic pyrrolidines have been synthesized in two
steps from common three‐to seven‐membered‐ring (hetero) alicyclic ketones. The key …

Fluorinated compounds, while rarely used by nature, are emerging as fundamental
ingredients in biomedical research, with applications in drug discovery, metabolomics …

The 2‐substituted piperidine core is found in drugs (18 FDA‐approved drugs), however,
their spirocyclic analogues remain unknown. Described here is the synthesis of spirocyclic …