The majority of acquired hearing loss, including presbycusis, is caused by irreversible
damage to the sensorineural tissues of the cochlea. This article reviews the intracellular …

Ca2+-ATPases (pumps) are key actors in the regulation of Ca2+ in eukaryotic cells and are
thus essential to the correct functioning of the cell machinery. They have high affinity for …

Mutations in Atp2b2, an outer hair cell gene, cause dominant hearing loss in humans. Using
a mouse model Atp2b2 Obl/+, with a dominant hearing loss mutation (Oblivion), we show …

Hair cells of the inner ear are essential for hearing and balance. As a consequence,
pathogenic variants in genes specifically expressed in hair cells often cause hereditary …

Much is known about the mechanotransducer (MT) channels mediating transduction in hair
cells of the vertrbrate inner ear. With the use of isolated preparations, it is experimentally …

Sound pressure fluctuations striking the ear are conveyed to the cochlea, where they vibrate
the basilar membrane on which sit hair cells, the mechanoreceptors of the inner ear …

Mechanotransduction—a cell's conversion of a mechanical stimulus into an electrical signal—
reveals vital features of an organism's environment. From hair cells and skin …

Cochlear hair cells respond with phenomenal speed and sensitivity to sound vibrations that
cause submicron deflections of their hair bundle. Outer hair cells are not only detectors, but …

The role of the cochlea is to transduce complex sound waves into electrical neural activity in
the auditory nerve. Hair cells of the organ of Corti are the sensory cells of hearing. The inner …

Sensorineural hearing loss is genetically heterogeneous. Here, we report that mutations in
CIB2, which encodes a calcium-and integrin-binding protein, are associated with …