The Na/K-ATPase (NKA), or Na pump, is a member of the P-type ATPase superfamily. In
addition to pumping ions across cell membrane, it is engaged in assembly of multiple …

The Na+-K+-ATPase (NKA) differs from most other ion transporters, not only in its capacity to
maintain a steep electrochemical gradient across the plasma membrane, but also as a …

In this brief review we discuss some aspects of the Na+ pump and its roles in mediating the
effects of ouabain and endogenous ouabain (EO): i) in regulating the cytosolic Ca 2+ …

Preeclampsia (PE), the most severe presentation of hypertensive disorders of pregnancy, is
the major cause of morbidity and mortality linked to pregnancy, affecting both mother and …

Bipolar disorder (BD) is a severe and common chronic mental illness characterized by
recurrent mood swings between depression and mania. The biological basis of the disease …

(BP). 22–26 Based on new insight into CNS and vascular signaling pathways in salt-
sensitive hypertension, 27, 28 the role of the brain in controlling circulating EO was recently …

Two prescient 1953 publications set the stage for the elucidation of a novel endocrine
system: Schatzmann's report that cardiotonic steroids (CTSs) are all Na+ pump inhibitors …

Since the discovery of ouabain as a cardiotonic steroid hormone present in higher
mammals, research about it has progressed rapidly and several of its physiological and …

There is a great need for treatment that arrests progression of chronic kidney disease.
Increased albumin in urine leads to apoptosis and fibrosis of podocytes and tubular cells …

Accumulating evidence obtained over the last three decades has revealed a
neuroendocrine system in the brain that mediates long term increases in blood pressure …