Highlights•This review collected the available evidence on the role of immunotherapy on
fertility, hypogonadism, and sexuality.•Immune checkpoint inhibitors could impair fertility.• …

Background: Over the past decades, advancements in oncological treatments have led to
major improvements in survival. Particularly for adolescents and young adults (AYAs) …

Cutaneous melanoma, the most aggressive type of skin cancer, remains one the most
represented forms of cancer in the United States and European countries, representing, in …

In recent years, the indications for immunotherapy in cancer treatment have been
expanding. The increased risk of cancer in young people, coupled with the fact that many …

Abstract Background Immune checkpoint inhibitors (ICIs) are widely used and may induce
long-term survival in various types of cancer. Yet, there is scarce evidence on potential …

The treatment landscape of solid tumors has changed markedly in the last years.
Molecularly targeted treatments and immunotherapies have been implemented and have, in …

Chimeric antigen receptor (CAR) T-cells serve to overcome chemotherapeutic resistance
and have been proven to be highly effective in B-cell hematologic malignancies. Although …

Simple Summary Immune checkpoint inhibitors (ICIs) are considered to be the standard of
care in multiple types of cancers. However, ICIs are implicated in a wide range of side …

Simple Summary Recently, a new type of cancer treatment called immune checkpoint
inhibitors (ICIs) has become an option for many cancer patients, including children. While …

Although the overall incidence and mortality of colorectal cancer have declined, diagnosed
cases of young-onset colorectal cancer have increased significantly. Concerns about future …