In vitro screens for nephrotoxicity are currently poorly predictive of toxicity in humans.
Although the functional proteins that are expressed by nephron tubules and mediate drug …

The kidney is a major target for drug-induced toxicity. Drug-induced nephrotoxicity remains a
major problem in the clinical setting, where the use of nephrotoxic drugs is often …

Cadmium (Cd) is an environmental toxicant of widespread exposure and pervasive toxicity.
Absorption, systemic transport and uptake of Cd are mediated by metal transporters that the …

The kidney proximal tubule is the primary site for solute reabsorption, secretion and where
kidney diseases can originate, including drug-induced toxicity. Two-dimensional cell culture …

Nephrotoxicity due to drugs and environmental chemicals accounts for significant patient
mortality and morbidity, but there is no high throughput in vitro method for predictive …

The number of successful drug development projects has been stagnant for decades
despite major breakthroughs in chemistry, molecular biology, and genetics. Unreliable target …

The renal proximal tubule is a main target for drug-induced toxicity. The prediction of
proximal tubular toxicity during drug development remains difficult. Any in vitro methods …

In toxicology, there is a strong push towards replacing animal experiments with alternative
methods, which include cell-based in vitro methods for the assessment of adverse health …

AKI affects approximately 13.3 million people around the world each year, causing CKD
and/or mortality. The mammalian kidney cannot generate new nephrons after postnatal …

Recent years have seen the creation and popularization of various complex in vitro models
(CIVMs), such as organoids and organs-on-chip, as a technology with the potential to …