Cellular senescence is characterized by irreversible cell cycle arrest in response to different
triggers and an inflammatory secretome. Although originally described in fibroblasts and cell …

Herein, we studied the impact of empty LNP (eLNP), component of mRNA-based vaccine,
on anti-viral pathways and immune function of cells from young and aged individuals. eLNP …

In the field of immunology, a systems biology approach is crucial to understanding the
immune response to infection and vaccination considering the complex interplay between …

Age is a major risk factor for severe coronavirus disease 2019 (COVID-19), yet the
mechanisms behind this relationship have remained incompletely understood. To address …

The immune system is a major regulatory system of the body, that is composed of immune
cells, immune organs, and related signaling factors. As an organism ages, observable age …

Background Age-associated impairments in innate immunity are believed to be a causative
factor responsible for severe pathogenesis of Staphylococcus aureus (S. aureus) infection in …

Age is a major risk factor for severe coronavirus disease-2019 (COVID-19), yet the
mechanisms responsible for this relationship have remained incompletely understood. To …

Results: The novel coronavirus, an acute respiratory syndrome caused by coronavirus 2,
has caused an epidemic of the coronavirus disease 2019 (COVID-19) that has infected …

Background At present, the etiology and mechanism of ovarian dysfunction are still unclear.
Recent studies have indicated a potential correlation between immunity and ovarian …

Age-related decline of immunity reduces vaccine efficacy in the elderly. Cellular senescence-
a hallmark of aging-is a physiological process characterized by a state of chronic low-grade …