Molecular control of HIV-1 postintegration latency: implications for the development of new therapeutic strategies
L Colin, C Van Lint - Retrovirology, 2009 - Springer
The persistence of HIV-1 latent reservoirs represents a major barrier to virus eradication in
infected patients under HAART since interruption of the treatment inevitably leads to a …
infected patients under HAART since interruption of the treatment inevitably leads to a …
[HTML][HTML] Genetic variation and function of the HIV-1 Tat protein
Human immunodeficiency virus type 1 (HIV-1) encodes a transactivator of transcription (Tat)
protein, which has several functions that promote viral replication, pathogenesis, and …
protein, which has several functions that promote viral replication, pathogenesis, and …
HIV-1 Tat primes and activates microglial NLRP3 inflammasome-mediated neuroinflammation
Neuroinflammation associated with HIV-1 infection is a problem affecting∼ 50% of HIV-
infected individuals. NLR family pyrin domain containing 3 (NLRP3) inflammasome has …
infected individuals. NLR family pyrin domain containing 3 (NLRP3) inflammasome has …
Single-cell transcriptional landscapes reveal HIV-1–driven aberrant host gene transcription as a potential therapeutic target
Understanding HIV-1–host interactions can identify the cellular environment supporting HIV-
1 reactivation and mechanisms of clonal expansion. We developed HIV-1 SortSeq to isolate …
1 reactivation and mechanisms of clonal expansion. We developed HIV-1 SortSeq to isolate …
[HTML][HTML] HIV-1 Tat protein induces DNA damage in human peripheral blood B-lymphocytes via mitochondrial ROS production
R El-Amine, D Germini, VV Zakharova, T Tsfasman… - Redox biology, 2018 - Elsevier
Human immunodeficiency virus (HIV) infection is associated with B-cell malignancies in
patients though HIV-1 is not able to infect B-cells. The rate of B-cell lymphomas in HIV …
patients though HIV-1 is not able to infect B-cells. The rate of B-cell lymphomas in HIV …
Expression of human endogenous retrovirus type K (HML-2) is activated by the Tat protein of HIV-1
MJ Gonzalez-Hernandez, MD Swanson… - Journal of …, 2012 - Am Soc Microbiol
Human endogenous retroviruses (HERVs) make up 8% of the human genome. The
expression of HERV-K (HML-2), the family of HERVs that most recently entered the genome …
expression of HERV-K (HML-2), the family of HERVs that most recently entered the genome …
Regulation of HIV-1 latency by T-cell activation
SA Williams, WC Greene - Cytokine, 2007 - Elsevier
HIV-infected patients harbor∼ 105–106 memory CD4 T-cells that contain fully integrated but
transcriptionally silent HIV proviruses. While small in number, these latently infected cells …
transcriptionally silent HIV proviruses. While small in number, these latently infected cells …
HIV UTR, LTR, and epigenetic immunity
J Zhang, C Crumpacker - Viruses, 2022 - mdpi.com
The duel between humans and viruses is unending. In this review, we examine the HIV RNA
in the form of un-translated terminal region (UTR), the viral DNA in the form of long terminal …
in the form of un-translated terminal region (UTR), the viral DNA in the form of long terminal …
Microglial HIV-1 expression: Role in HIV-1 associated neurocognitive disorders
H Li, KA McLaurin, JM Illenberger, CF Mactutus… - Viruses, 2021 - mdpi.com
The persistence of HIV-1 viral reservoirs in the brain, despite treatment with combination
antiretroviral therapy (cART), remains a critical roadblock for the development of a novel …
antiretroviral therapy (cART), remains a critical roadblock for the development of a novel …
Retracted: aging is associated with altered inflammatory, arachidonic acid cascade, and synaptic markers, influenced by epigenetic modifications, in the human frontal …
VL Keleshian, HR Modi, SI Rapoport… - Journal of …, 2013 - Wiley Online Library
Aging is a risk factor for Alzheimer's disease (AD) and is associated with cognitive decline.
However, underlying molecular mechanisms of brain aging are not clear. Recent studies …
However, underlying molecular mechanisms of brain aging are not clear. Recent studies …