Collagen-anchored interleukin-2 and interleukin-12 safely reprogram the tumor microenvironment in canine soft-tissue sarcomas
JA Stinson, A Sheen, N Momin, J Hampel… - Clinical Cancer …, 2023 - AACR
Purpose: Cytokine therapies such as IL2 and IL12 suffer from impractically small therapeutic
windows driven by their on-target, off-tumor activity, limiting their clinical potential despite …
windows driven by their on-target, off-tumor activity, limiting their clinical potential despite …
[HTML][HTML] An Abscopal Effect on Lung Metastases in Canine Mammary Cancer Patients Induced by Neoadjuvant Intratumoral Immunotherapy with Cowpea Mosaic …
P Sergent, JC Pinto-Cárdenas, AJA Carrillo… - Cells, 2024 - mdpi.com
Neoadjuvant intratumoral (IT) therapy could amplify the weak responses to checkpoint
blockade therapy observed in breast cancer (BC). In this study, we administered …
blockade therapy observed in breast cancer (BC). In this study, we administered …